Description

4,4,4-Trifluorobut-2-Enol (Cis) is a fluorinated building block of significant interest in advanced organic synthesis. This compound matters for its ability to introduce the trifluoromethyl group and an olefinic alcohol handle into complex molecular architectures, enabling the fine-tuning of physicochemical properties. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of fluorinated drug candidates, particularly in oncology and CNS therapeutic areas.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides where fluorine substitution enhances bioavailability and environmental stability.
• Liquid Crystal & OLED Material Precursor: Serves as a building block for fluorinated organic electronic materials.
• Advanced Polymer Modification: Incorporates fluorine functionality into specialty polymers to alter surface energy and chemical resistance.
• Cross-Coupling Reactions: Acts as a substrate in palladium-catalyzed reactions like Heck or Suzuki couplings to create complex fluorinated structures.
• Asymmetric Synthesis: The cis-configured double bond and chiral center make it a valuable substrate for stereoselective transformations.

Basic Information

Product Name	4,4,4-Trifluorobut-2-Enol (Cis)
CAS No.	83706-98-3
Molecular Formula	C4H5F3O
Molecular Weight	126.08 g/mol
Synonyms	(Z)-4,4,4-Trifluorobut-2-en-1-ol; cis-4,4,4-Trifluorobut-2-en-1-ol; (2Z)-4,4,4-Trifluoro-2-buten-1-ol; 4,4,4-Trifluoro-cis-but-2-en-1-ol; 4,4,4-Trifluoro-(Z)-2-buten-1-ol; (Z)-4,4,4-Trifluoro-2-butenol; cis-Trifluorobut-2-enol
EINECS	Contact for details

Quality Control

Our 4,4,4-Trifluorobut-2-Enol (Cis) is produced under strict quality management protocols. Every batch undergoes rigorous analytical testing, including GC/HPLC for purity and NMR for structural confirmation, to ensure compliance with exacting R&D and scale-up requirements. A comprehensive Certificate of Analysis (COA) detailing purity, isomeric ratio, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is sensitive to strong alkali and fluoride ions; ensure storage areas are free from such contaminants. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Isomeric Purity (cis-isomer)	≥ 95.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.