Description

Parvalbumin is a low molecular weight, high-affinity calcium-binding protein belonging to the EF-hand superfamily. It is a critical reagent in neuroscience and biomedical research, primarily valued for its role as a specific marker for a subpopulation of GABAergic inhibitory interneurons in the central nervous system. This product is essential for researchers and diagnostic developers in the fields of neurobiology, immunology, and allergy science, where precise protein characterization is required.

Application

• Neuroscience Research: Used as a definitive immunohistochemical marker for fast-spiking GABAergic interneurons in brain tissue studies.
• Immunological Assays: Serves as a key antigen in the development and validation of immunoassays for parvalbumin-specific antibody detection.
• Allergen Characterization: Employed in research to study cross-reactivity and epitope mapping due to its status as a major fish allergen.
• Calcium Signaling Studies: Utilized as a model protein to investigate calcium buffering and signal transduction mechanisms in cells.
• Diagnostic Development: Acts as a reference standard in the quality control of diagnostic kits for fish allergy testing.
• Biochemical Reagent: Used in protein interaction studies and as a control in electrophoresis and chromatography.

Basic Information

Product Name	Parvalbumin
CAS No.	83667-75-8
Molecular Formula	Contact for details
Molecular Weight	~12 kDa (typical for α-parvalbumin isoform)
Synonyms	Parvalbumin alpha; PVALB; Oncorhynchus mykiss parvalbumin beta; Fish major allergen parvalbumin; PRVB; Carp parvalbumin; Gad c 1 (Cod allergen); EF-hand domain-containing protein D1; Calcium-binding protein, parvalbumin type.
EINECS	Contact for details

Quality Control

Our Parvalbumin is produced and tested under a rigorous quality management system. Each batch is characterized to ensure identity, purity, and biological activity, meeting the exacting standards required for research and diagnostic applications. A comprehensive Certificate of Analysis (COA) detailing purity (by HPLC), identity (by immunoblot and/or mass spectrometry), endotoxin levels, and functional activity is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a dry environment before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (Immunoblot)	Positive reaction with anti-parvalbumin antibody
Purity (SDS-PAGE)	≥ 95%
Purity (HPLC)	≥ 90%
Protein Content (Biuret)	≥ 90% of dry weight
Calcium-Binding Activity	Functional by chelation assay
Endotoxin	< 1.0 EU/mg
Solubility	Soluble in aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.