Description

Dynorphin (1-24) CAS NO 83663-53-0 is a bioactive peptide fragment derived from the endogenous opioid peptide precursor prodynorphin. This compound is of significant interest in neuroscience and pharmacological research due to its role as a potent and selective agonist for the κ-opioid receptor (KOR). It is primarily utilized by research institutions, pharmaceutical R&D departments, and biotechnology companies engaged in the study of pain pathways, addiction mechanisms, and neuropsychiatric disorders.

Application

• Neuroscience Research: Used as a selective κ-opioid receptor agonist to study receptor signaling, neural circuitry, and behavioral effects in animal models.
• Pain Mechanism Studies: Investigates the role of the dynorphin/KOR system in modulating pain perception, stress-induced analgesia, and chronic pain states.
• Psychopharmacology: A key tool for researching the involvement of dynorphin in addiction, depression, anxiety, and other neuropsychiatric conditions.
• Drug Discovery & Development: Serves as a reference standard and pharmacological probe in the screening and development of novel analgesics and central nervous system (CNS) therapeutics.
• Biochemical Assays: Employed in in vitro binding assays, functional cell-based assays, and second messenger system studies to characterize KOR activity.
• Academic & Clinical Research: Supports fundamental and translational research into endogenous opioid systems and their physiological and pathological roles.

Basic Information

Item	Detail
Product Name	Dynorphin (1-24)
CAS No.	83663-53-0
Molecular Formula	C₁₂₉H₂₁₁N₃₉O₃₉
Molecular Weight	2848.3 g/mol
Synonyms	Dynorphin A (1-24); Dynorphin-24; Dynorphin A 1-24; Big Dynorphin (1-24); Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg-Pro-Lys-Leu-Lys-Trp-Asp-Asn-Gln-Lys-Arg-Tyr-Gly-Gly-Phe-Leu; Dynorphin A Fragment 1-24; Leumorphin (1-24); Porcine Dynorphin (1-24)
EINECS	Contact for details

Quality Control

Our Dynorphin (1-24) is produced and controlled under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity assessment, mass spectrometry (MS) for identity confirmation, and amino acid analysis (AAA). We provide a comprehensive Certificate of Analysis (COA) with each shipment, detailing purity, peptide content, and analytical results to ensure compliance with research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a dry environment before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by AAA)
Single Impurity (HPLC)	≤ 1.0%
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.