Description

Methyl n-Boc-L-Proline-4-Ene is a high-purity, protected amino acid derivative essential for advanced organic synthesis. This compound serves as a critical chiral building block for the construction of complex peptide mimetics and pharmaceutical intermediates. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutics, including protease inhibitors and constrained peptides.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for drugs targeting enzymatic pathways.
• Peptidomimetic Research: Used to introduce conformational constraints and novel scaffolds in the design of peptide-based drug candidates.
• Solid-Phase Peptide Synthesis (SPPS): Employed as a protected proline analog to incorporate unique structural features during automated peptide assembly.
• Medicinal Chemistry: Facilitates structure-activity relationship (SAR) studies by providing a versatile handle for further functionalization.
• Chemical Biology Probes: Utilized in the synthesis of labeled or tagged compounds for studying biological mechanisms and target engagement.
• Academic & Industrial R&D: Serves as a valuable reagent for methodological development in organic chemistry and asymmetric synthesis.

Basic Information

Product Name	Methyl n-Boc-L-Proline-4-Ene
CAS No.	83548-46-3
Molecular Formula	C12H19NO4
Molecular Weight	241.28 g/mol
Synonyms	1-(tert-Butoxycarbonyl)-4-methylene-L-proline methyl ester; (S)-1-((tert-Butoxycarbonyl)-4-methylenepyrrolidine-2-carboxylic acid methyl ester; Methyl (2S)-1-[(2-methylpropan-2-yl)oxycarbonyl]-4-methylenepyrrolidine-2-carboxylate; Boc-4-methylene-L-proline methyl ester; Methyl Boc-δ4-L-prolinate; Methyl 1-Boc-4-methylene-L-prolinate; L-Proline, 1-[(1,1-dimethylethoxy)carbonyl]-4-methylene-, methyl ester, (2S)-
EINECS	Contact for details

Quality Control

Our Methyl n-Boc-L-Proline-4-Ene is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and spectroscopic identification (NMR, IR). A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to ensure traceability and compliance with your research or cGMP requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C for long-term stability. The product is moisture-sensitive; keep the container tightly sealed under an inert atmosphere when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.