Description

[(Difluoromethyl)Thio]Acetic Acid Methyl Ester is a specialized organosulfur and organofluorine building block of significant interest in advanced chemical synthesis. This compound matters for its unique difluoromethylthio moiety, which is a valuable precursor for introducing the SCF2H group, a bioisostere with potential to modulate the physicochemical properties of target molecules. It is primarily needed by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the incorporation of the difluoromethylthio (SCF2H) group into drug candidates, potentially enhancing metabolic stability and membrane permeability.
• Agrochemical Synthesis: Used in the research and development of novel pesticides and herbicides, where the fluorine atoms can improve biological activity and environmental persistence.
• Material Science Research: Serves as a precursor for synthesizing functionalized materials with specific surface properties or for creating novel fluorinated polymers.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes to study enzyme mechanisms or protein interactions where a thioether linkage is required.
• Ligand and Catalyst Development: Useful for preparing novel ligands or catalysts in asymmetric synthesis and transition metal catalysis.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis projects requiring the introduction of fluorinated sulfur functionalities.

Basic Information

Product Name	[(Difluoromethyl)Thio]Acetic Acid Methyl Ester
CAS No.	83494-28-4
Molecular Formula	C5H6F2O2S
Molecular Weight	156.16 g/mol
Synonyms	Methyl [(Difluoromethyl)thio]acetate; Methyl 2-[(Difluoromethyl)thio]acetate; Acetic acid, [(difluoromethyl)thio]-, methyl ester; 2-[(Difluoromethyl)thio]acetic acid methyl ester; S-(Difluoromethyl) thioglycolic acid methyl ester; Methyl (difluoromethylthio)acetate; Methyl S-(difluoromethyl)mercaptoacetate
EINECS	Contact for details

Quality Control

Our [(Difluoromethyl)Thio]Acetic Acid Methyl Ester is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure high chemical purity and identity confirmation. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to guarantee traceability and compliance with your research or production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from incompatible materials such as strong bases and oxidizing agents. Due to its sensitivity to moisture and potential hydrolysis, the container should be kept tightly sealed under an inert atmosphere for long-term storage.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.