Description

Boc-His(3-Bom)-Ome Hcl is a protected derivative of the amino acid L-Histidine, specifically designed for use in peptide synthesis. This compound is a critical building block for researchers and manufacturers requiring precise control over the histidine side chain during complex peptide assembly. It is primarily utilized in the pharmaceutical and biotechnology sectors for the development of therapeutic peptides, research peptides, and other bioactive molecules. The product is supplied as a high-purity intermediate to ensure reliable and reproducible results in sensitive synthetic applications.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid derivative for the controlled incorporation of histidine into peptide chains.
• Pharmaceutical Research: Used in the research and development of novel peptide-based drugs and active pharmaceutical ingredients (APIs).
• Bioconjugation: Serves as a precursor for creating peptide conjugates for diagnostic or targeted drug delivery systems.
• Chemical Biology Studies: Employed in studies investigating protein-protein interactions and enzyme mechanisms where histidine modification is required.
• Custom Peptide Manufacturing: An essential raw material for contract research organizations (CROs) and CDMOs producing custom peptides for clients.

Basic Information

Product Name	Boc-His(3-Bom)-Ome Hcl
CAS No.	83468-80-8
Molecular Formula	C20H29N3O6 • HCl
Molecular Weight	460.92 g/mol (as free base)
Synonyms	Boc-His(Bom)-OMe•HCl; N-α-(tert-Butoxycarbonyl)-N-π-(benzyloxymethyl)-L-histidine methyl ester hydrochloride; Boc-L-histidine(N-π-Bom)-OMe hydrochloride; Methyl N-[(1,1-dimethylethoxy)carbonyl]-N-[3-[(benzyloxy)methyl]-1H-imidazol-4-yl]-L-alaninate hydrochloride; (S)-Methyl 2-((tert-butoxycarbonyl)amino)-3-(3-(benzyloxymethyl)-1H-imidazol-4-yl)propanoate hydrochloride; Boc-His(3-Bzl-OMe)-OMe•HCl (common abbreviation); Boc-His(Bzl-OMe)-OMe hydrochloride
EINECS	Contact for details

Quality Control

Our Boc-His(3-Bom)-Ome Hcl is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for demanding synthetic applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to industry best practices, and specifications can be aligned with customer requirements for research or cGMP-grade material.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Optical Rotation	Contact for details
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.5%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.