Description

Z-β-Glu(Otbu)-Oh CAS NO 83436-45-7 is a protected amino acid derivative, specifically a tert-butyl ester of a glutamic acid analog, widely used as a crucial building block in peptide synthesis. Its primary value lies in providing a protected side-chain carboxyl group, enabling selective deprotection and controlled coupling during the assembly of complex peptide sequences. This high-purity intermediate is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and life sciences sectors developing novel peptide-based therapeutics, diagnostics, and research tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid for the Fmoc/tBu strategy, facilitating the construction of complex peptides.
• Solution-Phase Peptide Synthesis: Used in classical solution methods for synthesizing peptide fragments and small peptides.
• Pharmaceutical Intermediate: Serves as a critical raw material in the research and production of active pharmaceutical ingredients (APIs) for peptide drugs.
• Bioconjugation & Labeling: Employed in the synthesis of peptide tags, linkers, and carriers for drug delivery systems and diagnostic agents.
• Biochemical Research: Used to prepare custom peptides for studying protein-protein interactions, enzyme substrates, and receptor ligands.
• Combinatorial Chemistry: A valuable building block in libraries for high-throughput screening and drug discovery.

Basic Information

Product Name	Z-β-Glu(Otbu)-Oh
CAS No.	83436-45-7
Molecular Formula	C₁₇H₂₃NO₆
Molecular Weight	337.37 g/mol
Synonyms	N-Carbobenzoxy-β-glutamic acid α-tert-butyl ester; Z-β-Glu(OtBu)-OH; N-(Benzyloxycarbonyl)-L-β-glutamic acid 1-tert-butyl ester; (2S)-2-{[(Benzyloxy)carbonyl]amino}pentanedioic acid 5-tert-butyl ester; Z-β-Glutamic acid α-tert-butyl ester; Z-β-Glu(OtBu); N-Cbz-β-glutamic acid α-tert-butyl ester; Benzyl N-[(1S)-4-(tert-butoxy)-1,4-dioxobutan-2-yl]carbamate
EINECS	Contact for details

Quality Control

Our Z-β-Glu(Otbu)-Oh is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for sensitive applications like pharmaceutical research. Each lot undergoes comprehensive analytical testing, including HPLC for purity and chiral integrity, NMR and IR for structural confirmation, and specific tests for residual solvents and moisture. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting compliance with our stringent specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0%
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.