Description

1H-Benzimidazole-2-Carboxylicacid,4-Fluoro-,Methylester(9Ci) is a high-purity fluorinated benzimidazole derivative, a crucial advanced pharmaceutical intermediate. This compound is valued for its role in synthesizing novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring precise molecular modification. It is primarily sought by research institutions and manufacturers in the pharmaceutical and agrochemical industries for developing new drug candidates and specialty chemicals.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel benzimidazole-based drug candidates, including potential antivirals, antifungals, and kinase inhibitors.
• Agrochemical Research: Used in developing new generations of fungicides and herbicides that leverage the benzimidazole scaffold for enhanced activity.
• Organic Synthesis: Serves as a versatile precursor in complex organic reactions, including palladium-catalyzed cross-couplings and nucleophilic substitutions, due to the reactive ester and fluorine groups.
• Material Science: Investigated as a monomer or additive for creating specialty polymers and advanced organic materials with specific electronic or thermal properties.
• Biochemical Tool Compound: Utilized in life science research as a probe or inhibitor to study specific enzymatic pathways and biological mechanisms.

Basic Information

Product Name	1H-Benzimidazole-2-Carboxylicacid,4-Fluoro-,Methylester(9Ci)
CAS No.	83431-75-8
Molecular Formula	C9H7FN2O2
Molecular Weight	194.16 g/mol
Synonyms	4-Fluoro-1H-benzimidazole-2-carboxylic acid methyl ester; Methyl 4-fluoro-1H-benzimidazole-2-carboxylate; 4-Fluoro-1H-benzo[d]imidazole-2-carboxylic acid methyl ester; 1H-Benzimidazole-2-carboxylic acid, 4-fluoro-, methyl ester; 83431-75-8; Methyl 4-fluorobenzimidazole-2-carboxylate; 4-Fluorobenzimidazole-2-carboxylic acid methyl ester
EINECS	Contact for details

Quality Control

Our 1H-Benzimidazole-2-Carboxylicacid,4-Fluoro-,Methylester(9Ci) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for critical research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Individual impurity ≤0.5%; Total impurities ≤1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.