Description

Metronidazole-D3 Solution is a deuterium-labeled isotopologue of the widely used nitroimidazole antibiotic and antiprotozoal agent, metronidazole. This stable isotope-labeled compound is an essential internal standard for the accurate quantification of metronidazole in complex biological matrices using advanced analytical techniques like LC-MS/MS. It is primarily required by pharmaceutical research laboratories, contract research organizations (CROs), and analytical testing facilities engaged in drug metabolism and pharmacokinetics (DMPK) studies, bioanalytical method development, and clinical trial sample analysis.

Application

• Bioanalytical Internal Standard: Serves as a critical internal standard for the precise and accurate quantification of metronidazole in plasma, serum, urine, and tissue homogenates via Liquid Chromatography-Mass Spectrometry (LC-MS/MS).
• Drug Metabolism Studies (DMPK): Used in pharmacokinetic (PK) and pharmacodynamic (PD) research to track drug absorption, distribution, metabolism, and excretion (ADME) with high specificity.
• Clinical Research & Therapeutic Drug Monitoring (TDM): Enables reliable measurement of metronidazole concentrations in patient samples during clinical trials and routine TDM to ensure therapeutic efficacy and safety.
• Veterinary Pharmaceutical Analysis: Applied in the analysis of metronidazole in veterinary medicine for residue testing and pharmacokinetic studies in animals.
• Forensic Toxicology: Utilized in forensic laboratories for the confirmatory analysis of metronidazole in cases of overdose or poisoning.
• Method Development & Validation: Essential for developing, validating, and transferring robust LC-MS/MS methods in compliance with regulatory guidelines (e.g., FDA, EMA).

Basic Information

Product Name	Metronidazole-D3 Solution
CAS No.	83413-09-6
Molecular Formula	C6H6D3N3O3
Molecular Weight	174.17 g/mol
Synonyms	2-Methyl-5-nitro-1H-imidazole-1-ethanol-d3; 1-(2-Hydroxyethyl)-2-methyl-5-nitroimidazole-d3; Deuterated Metronidazole; Metronidazole (methyl-d3); Metronidazole-d3; Flagyl-d3; Clont-d3
EINECS	Contact for details

Quality Control

Every batch of Metronidazole-D3 Solution is manufactured and analyzed under strict quality control protocols to ensure the highest standards of isotopic purity and chemical integrity, which are critical for its use as an analytical standard. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request, providing detailed results for isotopic enrichment, chemical purity, and solution concentration.

Storage

Preserve in a tightly closed container, protected from light. Store at recommended cold chain conditions (typically 2-8°C) to maintain solution stability and prevent degradation or solvent evaporation due to its volatile nature. Keep the container in a well-ventilated area, away from strong acids and oxidizing agents.

Specification

Item	Specification
Appearance	Clear, colorless to pale yellow solution
Identification (IR / NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0% (on anhydrous basis)
Isotopic Enrichment (MS)	≥ 99.0 atom % D
Chemical Purity (HPLC)	≥ 99.0%
Solvent	Methanol, Acetonitrile, or as specified
Concentration	Typically 1.0 mg/mL (or as customized)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.