Description

Substance P, Arg(1)-Pro(2)-Trp(7,9)-Leu(11)- CAS NO 83374-71-4 is a synthetic, site-specifically modified analog of the endogenous neuropeptide Substance P. This compound is engineered for enhanced stability and receptor selectivity, making it a critical research tool for studying neurokinin-1 (NK1) receptor signaling pathways and related physiological processes. It is primarily utilized by pharmaceutical researchers, academic institutions, and biotechnology companies engaged in neuroscience, pain research, and inflammatory disease studies.

Application

• Neuroscience Research: As a potent and selective NK1 receptor ligand for investigating the role of Substance P in neurotransmission, pain perception, and neurogenic inflammation.
• Pharmacological Studies: Used in in vitro and in vivo assays to screen and characterize potential antagonists for NK1 receptors.
• Biochemical Standard: Serves as a high-purity reference standard in analytical methods such as HPLC and mass spectrometry for peptide quantification and identification.
• Cell Signaling Research: Applied in studies of intracellular signaling cascades, calcium mobilization, and cytokine release mediated by NK1 receptor activation.
• Drug Discovery & Development: A key intermediate or tool compound in the development of novel therapeutics targeting neurological disorders, migraine, and emesis.

Basic Information

Product Name	Substance P, Arg(1)-Pro(2)-Trp(7,9)-Leu(11)- CAS NO 83374-71-4
CAS No.	83374-71-4
Molecular Formula	C63H98N20O13S
Molecular Weight	1359.65 g/mol
Synonyms	[Arg1, Pro2, Trp7,9, Leu11]-Substance P; Substance P (1-11), Arg1-Pro2-Trp7,9-Leu11-; Modified Substance P analog; NK1 receptor agonist analog; Neurokinin-1 receptor ligand; H-Arg-Pro-Lys-Pro-Gln-Gln-Trp-Phe-Trp-Leu-Leu-NH2 (modified sequence)
EINECS	Contact for details

Quality Control

Our Substance P analog is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, mass spectrometry for identity confirmation, and amino acid analysis. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with research-grade specifications. Our quality commitment supports reproducible and reliable experimental outcomes for our global clientele.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccant and under an inert atmosphere. Allow the vial to reach room temperature in a desiccator before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80%
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%
Single Impurity (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.