Description

H-Pro-Otbu Dibenzenesulfonimide is a high-purity, protected amino acid derivative and advanced pharmaceutical intermediate. This compound is valued for its role in facilitating complex peptide synthesis, particularly in the construction of proline-containing sequences where side-chain protection is critical. It is primarily utilized by research institutions and manufacturers in the pharmaceutical and biotechnology sectors for the development of novel therapeutic peptides and active pharmaceutical ingredients (APIs).

Application

• Peptide Synthesis: A key building block in solid-phase and solution-phase peptide synthesis (SPPS), especially for introducing proline residues with protected carboxylic acid groups.
• Pharmaceutical Intermediates: Serves as a critical intermediate in the research and production of peptide-based drugs, including hormone analogs and enzyme inhibitors.
• Bioconjugation: Used in the preparation of peptide conjugates for drug delivery systems and diagnostic probes.
• Chemical Biology Research: Employed in academic and industrial R&D for studying protein-protein interactions and developing peptide libraries.
• API Development: Integral to the process development and scale-up of new Active Pharmaceutical Ingredients (APIs) requiring specific chiral purity and protection schemes.

Basic Information

Product Name	H-Pro-Otbu Dibenzenesulfonimide
CAS No.	83283-35-6
Molecular Formula	C21H26N2O6S2
Molecular Weight	466.57 g/mol
Synonyms	N-[(tert-Butoxy)carbonyl]-L-proline N'-benzenesulfonylbenzenesulfonimide; Boc-Pro-OSu (Dibenzenesulfonimide salt); Boc-L-Proline Dibenzenesulfonimide Ester; tert-Butyloxycarbonyl-L-proline Dibenzenesulfonimide; H-Pro-OtBu·DBS; Boc-Pro-ODhbt; (S)-1-((tert-Butoxycarbonyl)pyrrolidine-2-carboxylic acid dibenzenesulfonimide
EINECS	Contact for details

Quality Control

Our H-Pro-Otbu Dibenzenesulfonimide is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation by IR and NMR spectroscopy, to ensure it meets the stringent requirements for pharmaceutical intermediate applications. Certificates of Analysis (COA) with full traceability are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.