Description

n-Boc-S-Bzl-L-Cys-Gly-Obzl is a protected dipeptide building block of significant importance in synthetic organic and medicinal chemistry. This compound is specifically designed for the controlled synthesis of complex peptides, offering orthogonal protection for both the amino and thiol side-chain functionalities. It is a critical intermediate for researchers and manufacturers in the pharmaceutical and biotechnology sectors, particularly in the development of peptide-based therapeutics, prodrugs, and novel chemical entities.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected intermediate for the sequential assembly of longer peptide chains, especially those containing cysteine residues.
• Solution-Phase Peptide Chemistry: Used in the synthesis of custom peptides, peptide fragments, and peptide conjugates in solution.
• Pharmaceutical Research & Development: Serves as a crucial building block in the discovery and development of peptide drugs, hormone analogs, and enzyme inhibitors.
• Bioconjugation and Linker Chemistry: The protected thiol (S-Bzl) group allows for selective deprotection and subsequent conjugation to other molecules, proteins, or surfaces.
• Combinatorial Chemistry Libraries: Employed in the generation of diverse peptide libraries for high-throughput screening against biological targets.
• Academic Research: A valuable reagent for studying peptide structure-activity relationships (SAR) and developing new synthetic methodologies.

Basic Information

Product Name	n-Boc-S-Bzl-L-Cys-Gly-Obzl
CAS No.	83283-22-1
Molecular Formula	C24H28N2O5S
Molecular Weight	456.55 g/mol
Synonyms	Boc-Cys(Bzl)-Gly-OBzl; N-(tert-Butoxycarbonyl)-S-benzyl-L-cysteinylglycine Benzyl Ester; Boc-L-Cysteine(S-benzyl)-Glycine Benzyl Ester; (2R)-2-[(2-{[(2-Methylpropan-2-yl)oxy]carbonyl}amino)-3-(benzylsulfanyl)propanamido]acetic Acid Benzyl Ester; tert-Butyl N-[(2R)-1-[(benzyloxy)-oxomethyl]-2-[(phenylmethyl)thio]ethyl]carbamate; Boc-Cys(Bzl)-Gly-OBzl; L-Cysteine, N-[(1,1-dimethylethoxy)carbonyl]-S-(phenylmethyl)-, 1-(benzyloxy)-1-oxo-2-(amino)ethyl ester
EINECS	Contact for details

Quality Control

Our n-Boc-S-Bzl-L-Cys-Gly-Obzl is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and spectroscopic methods for structural confirmation, to ensure it meets the high standards required for research and pharmaceutical applications. Certificates of Analysis (COA) with detailed specifications are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label/Certificate of Analysis. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Specific Rotation	-20° to -25° (c=1 in DMF)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.