Description

10-Hydroxywarfarin is a key hydroxylated metabolite of the anticoagulant drug warfarin. This compound is of significant importance in pharmaceutical research and development, particularly for studying drug metabolism, pharmacokinetics, and pharmacogenetics. It serves as a critical reference standard and intermediate for researchers and manufacturers in the pharmaceutical, analytical, and life science industries.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for the quantitative and qualitative analysis of warfarin and its metabolites in biological matrices.
• Drug Metabolism & Pharmacokinetics (DMPK) Studies: Essential for in vitro and in vivo studies to understand the metabolic pathways, clearance, and bioavailability of warfarin.
• Analytical Method Development: Serves as a critical standard for developing and validating HPLC, LC-MS/MS, and other chromatographic methods in clinical and forensic toxicology.
• Pharmacogenetic Research: Used in studies investigating the impact of genetic polymorphisms (e.g., in CYP2C9 enzyme) on warfarin dosing and patient response.
• Impurity Profiling: Employed as a known impurity or degradation product in the quality control of warfarin active pharmaceutical ingredient (API) and finished dosage forms.
• Biochemical Research: Utilized as a tool compound in enzymatic studies related to vitamin K epoxide reductase complex and coagulation cascades.

Basic Information

Item	Detail
Product Name	10-Hydroxywarfarin
CAS No.	83219-99-2
Molecular Formula	C19H16O6
Molecular Weight	340.33 g/mol
Synonyms	10-Hydroxywarfarin; 10-Hydroxy-4-hydroxy-3-(3-oxo-1-phenylbutyl)-2H-1-benzopyran-2-one; Warfarin, 10-hydroxy-; 4-Hydroxy-3-(3-oxo-1-phenylbutyl)-2H-1-benzopyran-2-one, 10-hydroxy-; 10-OH Warfarin; Warfarin 10-Hydroxy Metabolite
EINECS	Contact for details

Quality Control

Our 10-Hydroxywarfarin is produced and tested under a strict quality management system to ensure high purity and batch-to-batch consistency, suitable for research and analytical applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles, typically determined by advanced techniques like HPLC and LC-MS. We adhere to relevant industry guidelines for reference standard materials.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing at 2-8°C. Keep the container sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Individual impurity ≤ 1.0%
Total Impurities	≤ 2.0%
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.