Description

1-(Difluoromethoxy)-2-Methyl-4-Nitrobenzene is a high-purity fluorinated aromatic intermediate of significant importance in advanced organic synthesis. Its unique structure, featuring a difluoromethoxy group adjacent to a nitro substituent, makes it a valuable building block for creating complex molecules with tailored properties. This compound is primarily sought after by R&D and production teams in the pharmaceutical and agrochemical industries for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring fluorinated motifs to enhance metabolic stability, bioavailability, and binding affinity.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the difluoromethoxy group can improve efficacy and environmental profile.
• Material Science Research: Serves as a monomer or functionalization agent in the development of specialty polymers and liquid crystals with specific optical or electronic properties.
• Organic Synthesis Building Block: Employed in cross-coupling reactions, nucleophilic aromatic substitutions, and reduction chemistry to introduce complex aromatic systems into target molecules.

Basic Information

Product Name	1-(Difluoromethoxy)-2-Methyl-4-Nitrobenzene
CAS No.	83190-00-5
Molecular Formula	C8H7F2NO3
Molecular Weight	203.14 g/mol
Synonyms	2-Methyl-4-nitro-1-(difluoromethoxy)benzene; 4-Nitro-2-methylphenyl difluoromethyl ether; 1-Difluoromethoxy-2-methyl-4-nitrobenzene; 2-Methyl-4-nitrophenyl difluoromethyl ether; Benzene, 1-(difluoromethoxy)-2-methyl-4-nitro-; α,α-Difluoro-2-methyl-4-nitroanisole
EINECS	Contact for details

Quality Control

Our production of 1-(Difluoromethoxy)-2-Methyl-4-Nitrobenzene adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. Each lot is analyzed using advanced chromatographic and spectroscopic techniques (HPLC, GC, NMR) to verify identity, potency, and impurity profiles. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from strong bases and reducing agents.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥97.0%
Related Substances (HPLC)	Total impurities ≤3.0%
Melting Point	Contact for details
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.