Description

1-Bromo-2-(1,1,2,2-Tetrafluoroethoxy)Benzene is a specialized fluorinated aromatic building block of significant interest in advanced organic synthesis. This compound matters for its unique combination of a reactive bromine substituent and a highly fluorinated ether side chain, enabling precise molecular modifications. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients with enhanced properties.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly those requiring fluorinated motifs for improved metabolic stability, bioavailability, and membrane permeability.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides where the introduction of fluorine atoms can dramatically alter biological activity and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a precursor in the synthesis of fluorinated components for electronic display technologies and organic light-emitting diodes (OLEDs), where fluorine enhances thermal stability and electronic properties.
• Polymer & Specialty Chemicals: Employed to incorporate fluorinated aromatic units into polymers and specialty chemicals, imparting desirable characteristics such as chemical resistance, low surface energy, and thermal stability.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck, Sonogashira) to construct complex biaryl and conjugated systems.
• Fluorine Chemistry Research: A valuable reagent in academic and industrial research focused on exploring new methodologies in fluoroorganic chemistry and developing novel fluorinated compounds.

Basic Information

Product Name	1-Bromo-2-(1,1,2,2-Tetrafluoroethoxy)Benzene
CAS No.	83015-28-5
Molecular Formula	C8H5BrF4O
Molecular Weight	273.02 g/mol
Synonyms	2-Bromo-1-(1,1,2,2-tetrafluoroethoxy)benzene; o-Bromo(1,1,2,2-tetrafluoroethoxy)benzene; 1-Bromo-2-(tetrafluoroethoxy)benzene; Benzene, 1-bromo-2-(1,1,2,2-tetrafluoroethoxy)-; 2-(1,1,2,2-Tetrafluoroethoxy)bromobenzene; 2-Bromo-α,α,β,β-tetrafluoroanisole
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Each batch is characterized using advanced analytical techniques to guarantee identity, purity, and consistency. Certificates of Analysis (COA) detailing specific batch results are available upon request. We adhere to a quality management system to support our commitment to supplying high-purity research and process chemicals.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Recommended storage temperature is between 15°C and 25°C. Keep away from incompatible materials such as strong bases and fluorides. The container should be kept tightly sealed to prevent moisture absorption.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.