Description

2-(3,4-Dihydroxyphenyl)Ethyl-1,1-D2-Amine Hcl is a deuterium-labeled derivative of dopamine, a critical neurotransmitter and intermediate. This compound is specifically designed for use as an internal standard in analytical chemistry, enabling precise quantification and metabolic studies. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and diagnostic sectors who require high-fidelity isotopic tracers for mass spectrometry (LC-MS/MS, GC-MS) and advanced pharmacokinetic research.

Application

• Internal Standard for Bioanalysis: Primary use as a stable isotope-labeled internal standard in Liquid Chromatography-Mass Spectrometry (LC-MS/MS) for the accurate quantification of dopamine and related catecholamines in biological matrices (plasma, urine, tissue).
• Metabolic Pathway Tracing: Employed in pharmacological and neurological research to trace and study the metabolism, uptake, and degradation pathways of dopamine using deuterium as a non-radioactive tracer.
• Pharmaceutical Reference Standard: Serves as a certified reference material (CRM) for quality control and method validation in the development and production of dopaminergic drugs and neurological agents.
• Neurochemical Research: Used in fundamental neuroscience research to investigate receptor binding, synaptic transmission, and the role of dopamine in various neurological conditions and behaviors.
• Diagnostic Assay Development: A key component in the development of high-sensitivity clinical diagnostic assays for disorders related to dopamine dysregulation, such as Parkinson's disease.

Basic Information

Product Name	2-(3,4-Dihydroxyphenyl)Ethyl-1,1-D2-Amine Hcl
CAS No.	83008-33-7
Molecular Formula	C8H10D2ClNO2
Molecular Weight	189.66 g/mol
Synonyms	Dopamine-1,1-d2 Hydrochloride; 2-(3,4-Dihydroxyphenyl)ethyl-1,1-d2-amine hydrochloride; 4-(2-Aminoethyl)-1,2-benzenediol-1,1-d2 hydrochloride; 3,4-Dihydroxyphenethylamine-1,1-d2 HCl; 3-Hydroxytyramine-1,1-d2 hydrochloride; DA-d2 HCl; Deuterated Dopamine HCl (1,1-d2); (1,1-Dideutero-2-(3,4-dihydroxyphenyl)ethyl)amine hydrochloride
EINECS	Contact for details

Quality Control

Every batch of our 2-(3,4-Dihydroxyphenyl)Ethyl-1,1-D2-Amine Hcl is manufactured and analyzed under strict quality management systems. We guarantee high chemical and isotopic purity, with comprehensive characterization via NMR, MS, and HPLC. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, purity (typically ≥98% by HPLC), isotopic enrichment (≥98 atom % D), and absence of critical impurities. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical reference standards.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry, cool place. This compound is hygroscopic (moisture-sensitive) and must be kept under inert atmosphere (argon or nitrogen) after opening to prevent degradation. For long-term storage, desiccants are recommended.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (NMR/MS)	≥ 98 atom % D
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.