Description

n-[2-(Trifluoromethyl)-3H-Benzoimidazol-5-Yl]Acetamide is a high-value, fluorinated benzimidazole derivative, a specialized heterocyclic building block prized for its unique structural and electronic properties. This compound matters for its critical role in advanced pharmaceutical research and agrochemical development, where the trifluoromethyl group is a key pharmacophore known to enhance metabolic stability, lipophilicity, and bioavailability. It is primarily needed by R&D chemists and process development scientists in the life sciences sector for synthesizing novel active pharmaceutical ingredients (APIs), agrochemicals, and other fine chemicals.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of novel drug candidates, particularly in oncology, antiviral, and anti-inflammatory therapeutic areas.
• Agrochemical Synthesis: Used in the creation of advanced fungicides, herbicides, and insecticides, where the benzimidazole core and fluorine atoms contribute to biological activity.
• Material Science Research: Serves as a precursor for developing specialty polymers, liquid crystals, or organic electronic materials due to its rigid, aromatic structure.
• Biochemical Probe Development: Utilized in medicinal chemistry to create molecular probes for studying enzyme inhibition and biological pathway modulation.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring fluorinated heterocycles.

Basic Information

Product Name	n-[2-(Trifluoromethyl)-3H-Benzoimidazol-5-Yl]Acetamide
CAS No.	83003-97-8
Molecular Formula	C10H8F3N3O
Molecular Weight	243.19 g/mol
Synonyms	2-(Trifluoromethyl)-1H-benzimidazole-5-acetamide; 5-Acetamido-2-(trifluoromethyl)benzimidazole; 1H-Benzimidazole-5-acetamide, 2-(trifluoromethyl)-; Acetamide, N-[2-(trifluoromethyl)-1H-benzimidazol-5-yl]-; 83003-97-8; 2-Trifluoromethyl-1H-benzimidazole-5-ylacetamide
EINECS	Contact for details

Quality Control

Our n-[2-(Trifluoromethyl)-3H-Benzoimidazol-5-Yl]Acetamide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment supports compliance with cGMP and ICH guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (typically 15-25°C). The container should be kept tightly sealed in a dry environment to minimize exposure to moisture. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.