Description

Platelet Factor 4 (58-70) (Human) is a defined synthetic peptide fragment corresponding to residues 58-70 of the native human Platelet Factor 4 (PF4) protein. This high-purity reference standard is critical for research and development in hematology and immunology, providing a precise tool for studying platelet activation, heparin-induced thrombocytopenia (HIT), and related immune responses. It is essential for pharmaceutical R&D teams, clinical diagnostic manufacturers, and academic researchers focused on thrombosis, hemostasis, and autoimmune disease mechanisms. The product is supplied with full analytical characterization to ensure batch-to-batch consistency and reliability for sensitive assay development.

Application

• Reference Standard for Immunoassays: Used as a calibrated antigen in ELISA and other immunoassays for the detection of anti-PF4/heparin antibodies, crucial for diagnosing Heparin-Induced Thrombocytopenia (HIT).
• Biochemical Research: Serves as a key reagent in structure-activity relationship (SAR) studies to map antibody epitopes and understand the molecular basis of PF4-related disorders.
• Diagnostic Kit Development: Integral component in the development and quality control of in-vitro diagnostic (IVD) kits for thrombotic risk assessment.
• Pharmaceutical Screening: Employed in high-throughput screening (HTS) platforms to identify potential therapeutic compounds that modulate PF4-heparin interactions.
• Antigen for Antibody Production: Used to generate and characterize monoclonal and polyclonal antibodies specific to the PF4 (58-70) region.
• Academic & Clinical Studies: Supports fundamental research into platelet biology, vascular inflammation, and the pathophysiology of vaccine-induced immune thrombotic thrombocytopenia (VITT).

Basic Information

Item	Detail
Product Name	Platelet Factor 4 (58-70) (Human)
CAS No.	82989-21-7
Molecular Formula	C64H106N20O19S2
Molecular Weight	1491.8 g/mol
Synonyms	PF4 (58-70); Human Platelet Factor 4 Fragment 58-70; Platelet Factor 4 Peptide (58-70); LDMKKETLQRLKKE; H-PF4 (58-70); CXCL4 (58-70); Thrombocytin fragment; PF4 Heparin-binding domain peptide
EINECS	Contact for details

Quality Control

Every batch of Platelet Factor 4 (58-70) (Human) is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure identity, purity, and peptide content. Our quality system is designed to meet the exacting standards required for research and diagnostic applications. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing results for HPLC purity, amino acid analysis, mass spectrometry (MS) confirmation, and endotoxin levels.

Storage

Preserve in a tightly closed container, protected from light. Store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, keep under inert atmosphere. Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by amino acid analysis)
Amino Acid Sequence	LDMKKETLQRLKKE
Molecular Weight	1491.8 ± 1.0 Da (by MS)
Solubility	Soluble in water, dilute acetic acid
Endotoxin	< 1.0 EU/mg

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.