Description

L-Tyrosine, n-[(9H-Fluoren-9-Ylmethoxy)Carbonyl]-, Phenylmethyl Ester is a protected amino acid derivative, specifically an Fmoc (9-fluorenylmethoxycarbonyl) tyrosine benzyl ester, widely used as a critical building block in solid-phase peptide synthesis (SPPS). This compound is essential for researchers and manufacturers requiring high-purity intermediates to ensure the fidelity and yield of complex peptide sequences. It is primarily utilized by the pharmaceutical, biotechnology, and life sciences industries for the development of therapeutic peptides, research reagents, and novel bioactive compounds.

Application

• Solid-Phase Peptide Synthesis (SPPS): Serves as a key Fmoc-protected tyrosine derivative for the sequential assembly of custom peptides.
• Pharmaceutical Intermediates: Used in the research and production of peptide-based active pharmaceutical ingredients (APIs) and drug candidates.
• Bioconjugation & Labeling: Acts as a precursor for introducing tyrosine residues into molecules for subsequent labeling or cross-linking studies.
• Biochemical Research: Employed in academic and industrial laboratories for studying protein structure-function relationships and enzyme substrates.
• Combinatorial Chemistry: A valuable component in libraries for high-throughput screening to discover new bioactive molecules.
• Protecting Group Chemistry: Demonstrates the utility of orthogonal protecting groups (Fmoc for amine, benzyl for carboxyl) in complex organic synthesis.

Basic Information

Product Name	L-Tyrosine, n-[(9H-Fluoren-9-Ylmethoxy)Carbonyl]-, Phenylmethyl Ester
CAS No.	82911-77-1
Molecular Formula	C32H29NO5
Molecular Weight	507.58 g/mol
Synonyms	Fmoc-Tyr(Bzl)-OH; Fmoc-O-benzyl-L-tyrosine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-O-benzyl-L-tyrosine; Fmoc-L-tyrosine benzyl ester; Fmoc-Tyrosine(Bzl)-OH; N-Fmoc-O-benzyl-L-tyrosine; (2S)-3-(4-Benzyloxyphenyl)-2-[(9H-fluoren-9-ylmethoxy)formamido]propanoic acid; Fmoc-Tyr(Bn)-OH
EINECS	Contact for details

Quality Control

Our L-Tyrosine, n-[(9H-Fluoren-9-Ylmethoxy)Carbonyl]-, Phenylmethyl Ester is produced under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for sensitive synthetic applications. We provide comprehensive analytical data, including HPLC purity, chiral purity, and identity confirmation via spectroscopic methods. Certificates of Analysis (COA) are available for every batch upon request, detailing all relevant specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity ([α]D)	≥99.0% L-isomer
Loss on Drying	≤0.5%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.