Description

3-Dehydroxy Chlorthalidone is a key pharmaceutical intermediate and reference standard used in the development and quality control of active pharmaceutical ingredients (APIs). This compound is of significant value for research and manufacturing processes requiring high-purity chemical building blocks. It is primarily utilized by pharmaceutical R&D laboratories, API manufacturers, and analytical service providers involved in antihypertensive drug development and metabolite studies.

Application

• Pharmaceutical intermediate in the synthesis of antihypertensive agents and related compounds.
• Reference standard for analytical method development and validation in pharmaceutical quality control (QC) laboratories.
• Metabolite standard for pharmacokinetic and drug metabolism studies.
• Key starting material (KSM) or advanced intermediate in process chemistry research.
• Impurity standard for monitoring and controlling related substances in chlorthalidone and similar API manufacturing.
• Research chemical for investigating structure-activity relationships (SAR) in medicinal chemistry.

Basic Information

Product Name	3-Dehydroxy Chlorthalidone
CAS No.	82875-49-8
Molecular Formula	C14H11ClN2O3S
Molecular Weight	322.77 g/mol
Synonyms	3-Deshydroxy Chlorthalidone; 2-Chloro-5-(1-hydroxy-3-oxo-2,3-dihydro-1H-isoindol-1-yl)benzenesulfonamide; 1-Oxo-2-(2-chloro-5-sulfamoylphenyl)isoindoline; Chlorthalidone Impurity; Chlorthalidone Related Compound; 3-Deshydroxychlorthalidone; 82875-49-8
EINECS	Contact for details

Quality Control

Our 3-Dehydroxy Chlorthalidone is manufactured under a quality management system and undergoes rigorous analytical testing to ensure high purity and consistency. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing purity, identity, and impurity profiles. The product is suitable for use as a pharmaceutical reference standard and intermediate under current Good Manufacturing Practice (cGMP) principles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.