Description

Leukotriene D-4 Sulfone is a stable sulfone derivative of the potent inflammatory mediator leukotriene D4 (LTD4). This compound is of significant value as a key reference standard and a crucial biochemical tool in inflammation and respiratory disease research. It is primarily needed by pharmaceutical R&D laboratories, contract research organizations (CROs), and academic institutions focused on developing and validating assays for leukotriene pathway analysis.

Application

• Pharmaceutical Reference Standard: Used for the calibration and validation of analytical methods (HPLC, LC-MS) in drug development targeting the cysteinyl leukotriene pathway.
• Biochemical Research: Serves as a stable analog or metabolite in studies investigating the role of leukotrienes in asthma, allergic rhinitis, and other inflammatory conditions.
• Enzyme Inhibition Studies: Employed as a substrate or inhibitor in assays for enzymes like leukotriene C4 synthase or γ-glutamyl transpeptidase.
• Receptor Binding Assays: Utilized in competitive binding experiments to study the affinity and pharmacology of LTD4 receptor antagonists.
• Metabolite Identification: Acts as a critical standard for the identification and quantification of leukotriene metabolites in biological samples.
• Quality Control: Essential for the quality assurance and stability testing of leukotriene-modulating pharmaceuticals in manufacturing environments.

Basic Information

Product Name	Leukotriene D-4 Sulfone
CAS No.	82850-10-0
Molecular Formula	C25H39NO7S2
Molecular Weight	529.71 g/mol
Synonyms	LTD4 Sulfone; 5(S)-Hydroxy-6(R)-(cysteinylglycin-1-yl)-7,9-trans-11,14-cis-eicosatetraenoic Acid 1,1-Dioxide; Leukotriene D4 Sulfone; (5S,6R)-7-[(1R,2E,4E,6Z,9Z)-1-[(2S)-2-Amino-2-carboxyethyl]sulfonyl-2,4,6,9-heptadecatetraen-1-yl]-5,6-epoxynonanoic Acid; N-Acetyl LTE4 Sulfone (related metabolite); Cysteinyl Leukotriene D4 Sulfone
EINECS	Contact for details

Quality Control

Our Leukotriene D-4 Sulfone is produced and handled under strict quality management protocols to ensure batch-to-batch consistency and reliability for critical research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles, generated using validated analytical methods. We support compliance with relevant GMP/GLP guidelines for reference standards.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere. Allow the sealed container to reach room temperature before opening to minimize moisture condensation. Keep the container in a dry, well-ventilated area dedicated for biochemical storage.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.