Description

o-Isopropylguanosine is a chemically modified nucleoside analog of guanosine, where an isopropyl group is introduced at the ortho position of the ribose sugar. This structural modification is critical for enhancing its stability and bioavailability in advanced pharmaceutical and biochemical research applications. It serves as a key synthetic intermediate and building block for the development of novel antiviral agents, nucleotide-based prodrugs, and modified oligonucleotides. Researchers and manufacturers in pharmaceutical R&D, biotechnology, and fine chemical synthesis require this high-purity compound for developing next-generation therapeutic candidates.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of novel antiviral and anticancer nucleotide analogs.
• Biochemical Research: Used in studies investigating RNA metabolism, enzyme mechanisms, and nucleoside transport.
• Prodrug Development: Serves as a precursor for designing lipophilic prodrugs to improve cellular uptake of active nucleoside agents.
• Oligonucleotide Synthesis: Employed in the creation of modified oligonucleotides for diagnostic assays and therapeutic aptamers.
• Enzyme Substrate Studies: Acts as a substrate or inhibitor for kinases, phosphorylases, and other nucleoside-processing enzymes.
• Reference Standard: Utilized as a high-purity analytical standard in quality control laboratories for method development and validation.

Basic Information

Product Name	o-Isopropylguanosine
CAS No.	82773-20-4
Molecular Formula	C13H19N5O5
Molecular Weight	325.32 g/mol
Synonyms	9-[(2R,3R,4R,5R)-3,4-Dihydroxy-5-(hydroxymethyl)-3-isopropyloxolan-2-yl]-1,9-dihydro-6H-purin-6-one; 2'-O-Isopropylguanosine; 2'-O-(1-Methylethyl)guanosine; Guanosine, 2'-O-(1-methylethyl)-; o-iPrG; 2'-O-Isopropyl-Guanosine
EINECS	Contact for details

Quality Control

Our o-Isopropylguanosine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research and development. Each lot undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and tests for residual solvents and moisture. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support compliance with cGMP and ISO guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, consider desiccants and an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.