Description

n-α-Boc-L-Tryptophanol CAS NO 82689-19-8 is a protected amino alcohol derivative of the essential amino acid L-tryptophan, featuring a tert-butoxycarbonyl (Boc) protecting group on the α-amine. This compound is a crucial chiral building block in the synthesis of complex peptides and peptidomimetics, offering precise stereochemical control. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the development of therapeutic agents, including peptide-based drugs and enzyme inhibitors.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of peptide-based active pharmaceutical ingredients (APIs) and drug candidates.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis (SPPS) as a protected tryptophan derivative to prevent side reactions.
• Bioconjugation & Probe Development: Serves as a precursor for fluorescent probes or affinity labels due to the intrinsic fluorescence of the indole moiety.
• Chemical Biology Research: Employed in the study of enzyme-substrate interactions and the development of enzyme inhibitors.
• Asymmetric Synthesis: Acts as a chiral auxiliary or starting material in the asymmetric synthesis of non-natural amino acids and complex organic molecules.
• Protecting Group Chemistry: Demonstrates the utility of the Boc protecting group, which is cleavable under mild acidic conditions.

Basic Information

Product Name	n-α-Boc-L-Tryptophanol
CAS No.	82689-19-8
Molecular Formula	C₁₈H₂₆N₂O₃
Molecular Weight	318.41 g/mol
Synonyms	Boc-L-Tryptophanol; (S)-2-((tert-Butoxycarbonyl)amino)-3-(1H-indol-3-yl)propan-1-ol; N-Boc-L-tryptophanol; Boc-Trp-ol; tert-Butyl (S)-(1-hydroxy-3-(1H-indol-3-yl)propan-2-yl)carbamate; (S)-2-(Boc-amino)-3-(3-indolyl)-1-propanol; N-α-Boc-L-tryptophanol; L-Tryptophanol, N-Boc-
EINECS	Contact for details

Quality Control

Our n-α-Boc-L-Tryptophanol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and spectroscopic identification. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to ensure compliance with your research and production standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.