Description

N(Epsilon)-Acetimidoglucagon, Des-His(1)- is a chemically modified analog of the peptide hormone glucagon, designed for advanced biochemical and pharmaceutical research. This derivative is critical for studying glucagon receptor interactions, signal transduction pathways, and the development of novel therapeutic agents targeting metabolic disorders. It serves as a key intermediate and reference standard for researchers and developers in the fields of endocrinology, diabetes research, and peptide-based drug discovery.

Application

• Biochemical Research: Used as a high-purity reference standard in receptor binding assays and activity studies.
• Pharmaceutical Development: Serves as a critical intermediate in the synthesis and screening of novel glucagon receptor modulators and antidiabetic drugs.
• Metabolic Disorder Studies: Essential for investigating the role of glucagon in glucose homeostasis, liver metabolism, and related disease mechanisms.
• Peptide Chemistry: A valuable building block for the synthesis of more complex, site-specifically modified glucagon analogs.
• Academic & Institutional Research: Supports fundamental research in university and government laboratories focused on hormone action and peptide engineering.

Basic Information

Product Name	N(Epsilon)-Acetimidoglucagon, Des-His(1)-
CAS No.	82637-01-2
Molecular Formula	C148H226N42O49S
Molecular Weight	~3350.7 g/mol
Synonyms	Des-His(1)-Glucagon, Nε-Acetimido; Nε-Acetimidoglucagon (1-29), Des-His(1)-; Glucagon (2-29), Nε-Acetimido-; Acetimidated Des-His(1)-Glucagon; [Nε-Acetimido-Lys12]-Glucagon (2-29); Glucagon Analog, Des-His(1), Nε-Acetimido; 82637-01-2; Lys12(Nε-Acetimido)-Des-His1-Glucagon
EINECS	Contact for details

Quality Control

Our N(Epsilon)-Acetimidoglucagon, Des-His(1)- is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity suitable for research applications. Each lot undergoes comprehensive analytical characterization, including HPLC for purity, mass spectrometry for identity confirmation, and amino acid analysis. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, keep desiccated. Allow the vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Peptide Content	≥ 80.0%
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%
Single Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.