Description

2-Bromo-4-Hydroxybenzonitrile is a halogenated aromatic nitrile compound that serves as a versatile and valuable synthetic intermediate in advanced organic chemistry. Its molecular structure, featuring both a bromine substituent and a hydroxyl group, makes it a critical building block for constructing complex molecules with specific electronic and steric properties. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries who require high-purity intermediates for developing active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules requiring a bromophenol or cyanophenol core structure.
• Agrochemical Synthesis: Used in the development of herbicides, fungicides, and insecticides, where the bromine atom facilitates further coupling reactions.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized ligands used in metal-catalyzed cross-coupling reactions, such as Suzuki or Buchwald-Hartwig amination.
• Material Science Research: Employed in the synthesis of monomers for advanced polymers, liquid crystals, or organic electronic materials due to its functional group versatility.
• Chemical Biology Probes: Useful for synthesizing molecular probes and tags for studying biological systems, leveraging the reactivity of the bromine and nitrile groups.
• Custom Synthesis and R&D: A fundamental reagent for contract research organizations (CROs) and R&D laboratories engaged in novel compound library generation and medicinal chemistry.

Basic Information

Product Name	2-Bromo-4-Hydroxybenzonitrile
CAS No.	82380-17-4
Molecular Formula	C7H4BrNO
Molecular Weight	198.02 g/mol
Synonyms	4-Hydroxy-2-bromobenzonitrile; 2-Bromo-4-cyanophenol; 2-Bromo-4-hydroxybenzenecarbonitrile; 4-Cyano-3-bromophenol; Benzonitrile, 2-bromo-4-hydroxy-; 2-Brom-4-hydroxybenzonitril (German); 2-ブロモ-4-ヒドロキシベンゾニトリル (Japanese)
EINECS	Contact for details

Quality Control

Our 2-Bromo-4-Hydroxybenzonitrile is produced under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and FTIR, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, documenting all critical parameters. Our quality commitment ensures the material meets the stringent requirements for research and commercial synthesis applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be amber-colored or stored in dark conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Melting Point	145 - 150 °C
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals (as Pb)	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.