Description

Nimodipine Metabolite 3 is a key intermediate and reference standard in pharmaceutical research and development. This compound is critical for analytical method development, pharmacokinetic studies, and impurity profiling related to the calcium channel blocker Nimodipine. It is primarily utilized by pharmaceutical companies, contract research organizations (CROs), and analytical laboratories engaged in drug metabolism and safety evaluation.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for the identification and quantification of Nimodipine metabolites in biological matrices and drug formulations.
• Metabolite Research: Essential for studying the metabolic pathways, pharmacokinetics, and bioavailability of Nimodipine in preclinical and clinical research.
• Impurity Profiling: Serves as a known impurity standard for quality control testing of Nimodipine Active Pharmaceutical Ingredient (API) and finished drug products to ensure compliance with ICH guidelines.
• Analytical Method Development: Employed in the development and validation of HPLC, LC-MS, and other chromatographic methods for accurate metabolite detection.
• Dosage Form Development: Aids in formulation studies to understand degradation products and ensure drug product stability.

Basic Information

Product Name	Nimodipine Metabolite 3
CAS No.	82219-48-5
Molecular Formula	C21H26N2O7
Molecular Weight	418.44 g/mol
Synonyms	1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 2-methoxyethyl 1-methylethyl ester; Isopropyl 2-methoxyethyl 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid ester; Nimodipine Impurity; Nimodipine Related Compound; 3-Nitrophenyl DHP derivative; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our Nimodipine Metabolite 3 is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identity confirmation by spectroscopic methods (IR, NMR) and purity assessment by HPLC to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided for traceability and regulatory compliance.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing at 2-8°C. Handle the material in accordance with good laboratory practices.

Specification

Item	Specification
Appearance	Off-white to light yellow powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Related Substances (HPLC)	Single impurity ≤ 2.0%; Total impurities ≤ 5.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.