Description

Cefotetandisodium is the disodium salt form of Cefotetan, a second-generation broad-spectrum cephalosporin antibiotic. This compound is a critical active pharmaceutical ingredient (API) valued for its stability and efficacy against a wide range of Gram-positive and Gram-negative bacteria. It is primarily utilized by pharmaceutical manufacturers in the production of injectable antibiotic formulations for clinical use. Cefotetandisodium CAS NO 82189-60-4 is essential for developing treatments for serious infections, including intra-abdominal, urinary tract, and gynecological infections.

Application

• Pharmaceutical API: Primary use as the active ingredient in sterile injectable antibiotic drugs.
• Hospital Formulations: Manufacture of ready-to-use or reconstitutable powders for intravenous or intramuscular administration.
• Anti-infective Drug Development: Serves as a key intermediate in R&D for new antibiotic combinations and delivery systems.
• Veterinary Medicine: Potential application in developing antibacterial treatments for veterinary use.
• Reference Standard: Used as a certified reference material (CRM) in quality control laboratories for analytical testing.
• Clinical Research: Employed in studies investigating the efficacy and pharmacokinetics of cephem antibiotics.

Basic Information

Product Name	Cefotetandisodium
CAS No.	82189-60-4
Molecular Formula	C17H15N7Na2O8S4
Molecular Weight	659.57 g/mol
Synonyms	Cefotetan Disodium; Cefotetan Sodium; (6R,7R)-7-[[(4-(2-Amino-1-carboxy-2-oxoethylidene)-1,3-dithietan-2-yl)carbonyl]amino]-7-methoxy-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate Disodium Salt; ICI 156834; YM 09330; Apatef; Cefotan; Cefotetan Disodium Salt
EINECS	Contact for details

Quality Control

Our Cefotetandisodium is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets high-purity standards suitable for pharmaceutical applications. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with specifications for identity, purity, and impurities. We support compliance with cGMP (current Good Manufacturing Practice) guidelines and relevant pharmacopeial standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms
Identification (HPLC)	Conforms
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 5.0%
pH (10% solution)	4.5 - 6.5
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Bacterial Endotoxins	< 0.10 EU/mg
Sterility (if required)	Sterile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.