Description

Dl-Leucine-1-13C is a stable isotope-labeled analog of the essential branched-chain amino acid leucine, where the carbon atom at the 1-position is enriched with the 13C isotope. This compound is a critical tool in metabolic research, enabling precise tracking and quantification of amino acid flux, protein synthesis, and metabolic pathways using techniques like mass spectrometry and NMR spectroscopy. It is essential for researchers and manufacturers in the pharmaceutical, nutritional science, and biochemical diagnostics sectors who require high-purity, isotopically labeled standards for advanced studies.

Application

• Metabolic Pathway Tracing: Used as a stable isotope tracer in in vitro and in vivo studies to investigate leucine metabolism, protein turnover, and energy regulation.
• Biomedical Research & Drug Development: Serves as an internal standard in quantitative proteomics, metabolomics, and pharmacokinetic studies for accurate mass spectrometry analysis.
• Nutritional Science: Employed in clinical research to study amino acid requirements, muscle protein synthesis, and the metabolic effects of dietary supplements.
• Diagnostic Reagent Manufacturing: A key component in the production of calibrated assays and diagnostic kits for metabolic disorders.
• Isotope Dilution Mass Spectrometry (IDMS): Provides a reference standard for the absolute quantification of leucine and related metabolites in complex biological samples.

Basic Information

Product Name	Dl-Leucine-1-13C
CAS No.	82152-65-6
Molecular Formula	C6H13NO2 (with 13C at position 1)
Molecular Weight	132.17 g/mol (13C labeled)
Synonyms	(±)-2-Amino-4-methylpentanoic acid-1-13C; DL-Leucine-1-13C; rac-Leucine-1-13C; 13C Labeled DL-Leucine; 1-13C-Leucine; 2-Azaniumyl-4-methylpentanoate-1-13C; Isotopic leucine; Leucine-1-13C (racemic)
EINECS	Contact for details

Quality Control

Every batch of Dl-Leucine-1-13C is produced and tested under strict quality management systems to ensure exceptional isotopic and chemical purity, critical for sensitive analytical applications. Our standard specifications meet the rigorous demands of research and diagnostic manufacturing. A comprehensive Certificate of Analysis (COA) detailing isotopic enrichment (typically >99 atom % 13C), chemical purity (by HPLC), and identity confirmation is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to prevent absorption of atmospheric moisture, which can affect stability and analytical performance.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment (13C)	≥ 99 atom %
Optical Rotation	Specific rotation provided on COA
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.