Description

1-Chloro-4-(Difluoromethoxy)Benzene is a versatile fluorinated aromatic building block of significant industrial importance. Its unique structure, featuring both chlorine and difluoromethoxy substituents, makes it a critical intermediate for synthesizing advanced molecules with tailored properties. This compound is essential for R&D and production in the pharmaceutical and agrochemical sectors, where it is used to introduce fluorine-containing motifs that enhance biological activity, metabolic stability, and lipophilicity.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in the synthesis of drug candidates targeting central nervous system (CNS) disorders, anti-inflammatory agents, and antimicrobials.
• Agrochemical Synthesis: Serves as a crucial precursor in the manufacture of modern herbicides, fungicides, and insecticides, where the difluoromethoxy group can improve efficacy and environmental profile.
• Liquid Crystal Materials: Used in the research and production of fluorinated liquid crystals for advanced display technologies (LCDs), contributing to improved electro-optical properties.
• Organic Electronics: Employed as a building block for novel organic semiconductors and charge-transport materials used in OLEDs and organic photovoltaics.
• Specialty Polymer Modifier: Incorporated into polymer chains to alter physical properties such as chemical resistance, thermal stability, and surface energy for high-performance materials.
• Chemical Research & Development: A valuable reagent for exploring new fluorination methodologies and creating novel chemical entities in academic and industrial laboratories.

Basic Information

Product Name	1-Chloro-4-(Difluoromethoxy)Benzene
CAS No.	81932-03-8
Molecular Formula	C7H5ClF2O
Molecular Weight	178.56 g/mol
Synonyms	4-Chloro-α,α-difluoroanisole; p-Chloro-α,α-difluoroanisole; 1-Chloro-4-(difluoromethoxy)benzene; 4-Chlorophenyl difluoromethyl ether; Difluoromethoxy-4-chlorobenzene; (4-Chlorophenoxy)difluoromethane; Benzene, 1-chloro-4-(difluoromethoxy)-; p-Chlorophenyl difluoromethyl ether
EINECS	Contact for details

Quality Control

Our 1-Chloro-4-(Difluoromethoxy)Benzene is manufactured under a strict quality management system. Every batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure high chemical purity and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment ensures the material meets the stringent requirements for use in regulated synthesis applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed when not in use to prevent moisture absorption and maintain product integrity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms
Purity (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (GC)	≤ 2.0% (total)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.