Description

Coenzyme A Persulfide is a critical sulfur-containing derivative of coenzyme A, playing a fundamental role in cellular sulfur metabolism and redox signaling. This compound is essential for researchers and manufacturers focused on elucidating and modulating biochemical pathways related to hydrogen sulfide (H₂S) production and oxidative stress response. It is primarily utilized in advanced biochemical research, pharmaceutical development for cardiovascular and neurological applications, and the production of high-purity reference standards.

Application

• Biochemical Research: A key reagent for studying enzymatic mechanisms in sulfur transfer, particularly in the biosynthesis of iron-sulfur clusters and the regulation of H₂S-producing enzymes like cystathionine γ-lyase (CSE).
• Pharmaceutical R&D: Investigated as a precursor or modulator in drug discovery programs targeting diseases related to oxidative stress, ischemia-reperfusion injury, and inflammation.
• Reference Standard: Serves as a high-purity analytical standard for quality control in the production of related biochemicals and for calibration in chromatographic (HPLC, LC-MS) analyses.
• Metabolomics Studies: Used in profiling sulfur metabolites to understand metabolic disorders and the impact of therapeutic interventions on sulfur amino acid pathways.
• Enzyme Activity Assays: Employed as a substrate or cofactor in in vitro assays to measure the activity of sulfurtransferases and other relevant enzymes.

Basic Information

Product Name	Coenzyme A Persulfide
CAS No.	81918-99-2
Molecular Formula	C21H36N7O16P3S2
Molecular Weight	823.64 g/mol
Synonyms	CoA-SSH; Coenzyme A disulfide; Persulfidated Coenzyme A; CoA persulfide; 3'-dephospho-CoA persulfide; Coenzyme A hydrogen persulfide; Sulfurated Coenzyme A
EINECS	Contact for details

Quality Control

Our Coenzyme A Persulfide is produced under stringent conditions to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to rigorous internal quality standards and can support development under cGMP guidelines for pharmaceutical-grade material upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to minimize oxidation and hydrolysis. The material is hygroscopic (moisture-sensitive) and should be handled in a dry environment. Allow the vial to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder or lyophilized solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Assay (HPLC)	≥ 95%
Purity (HPLC)	≥ 98%
Water Content (KF)	≤ 2.0%
Solubility	Soluble in water or appropriate buffer

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.