Description

5-Hydroxy Propranolol is a key metabolite and synthetic intermediate of the widely used β-blocker, propranolol. This compound is of significant importance for pharmaceutical research and development, particularly in metabolism studies, pharmacokinetic profiling, and the synthesis of novel drug candidates. It is primarily needed by pharmaceutical R&D laboratories, analytical reference standard producers, and manufacturers of active pharmaceutical ingredients (APIs) for quality control and regulatory compliance purposes.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for the quantitative and qualitative analysis of propranolol and its metabolites in biological matrices and pharmaceutical formulations.
• Metabolite Research: Essential for in vitro and in vivo studies investigating the metabolic pathways, bioavailability, and clearance mechanisms of propranolol.
• Analytical Method Development: Serves as a critical standard for developing and validating analytical methods such as HPLC, LC-MS/MS, and GC-MS in clinical and forensic toxicology.
• Chemical Synthesis: Acts as a valuable building block or intermediate in the organic synthesis of propranolol analogs and related β-adrenergic blocking agents for structure-activity relationship (SAR) studies.
• Impurity Profiling: Employed to identify, quantify, and monitor process-related impurities and degradation products in propranolol API manufacturing, ensuring compliance with ICH guidelines.
• Pharmacology Studies: Utilized to assess the activity and potency of propranolol metabolites, contributing to a comprehensive understanding of its therapeutic and side effects.

Basic Information

Product Name	5-Hydroxy Propranolol
CAS No.	81907-82-6
Molecular Formula	C16H21NO3
Molecular Weight	275.35 g/mol
Synonyms	5-Hydroxypropranolol; 1-[(1-Methylethyl)amino]-3-(naphthalen-1-yloxy)propan-2-ol; 1-(Isopropylamino)-3-(1-naphthyloxy)-2-propanol; Propranolol Metabolite I; 5-OH-Propranolol; 1-Naphthalenol, 1-[(1-methylethyl)amino]-3-(1-naphthalenyloxy)-2-propanol; 4'‑Hydroxypropranolol (related positional isomer)
EINECS	Contact for details

Quality Control

Our 5-Hydroxy Propranolol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including identity confirmation by spectroscopic methods (IR, NMR), purity assessment by HPLC, and control of specific impurities. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all test results against established specifications. Our quality commitment ensures material suitable for research and development applications, including use as a reference standard.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.