Description

Rac 7-Hydroxy Propranolol CAS NO 81907-81-5 is a key metabolite and synthetic intermediate of the widely used β-blocker, propranolol. This compound is of significant importance for pharmaceutical research and development, particularly in metabolism studies, pharmacokinetic profiling, and the synthesis of reference standards. It is primarily needed by pharmaceutical companies, contract research organizations (CROs), and academic institutions engaged in cardiovascular drug development, analytical method validation, and impurity characterization.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for the quantification of propranolol and its metabolites in biological matrices and finished drug products.
• Metabolite Research: Critical for in vitro and in vivo studies investigating the metabolic pathways, bioavailability, and clearance mechanisms of propranolol.
• Impurity Profiling: Serves as a known impurity standard in the quality control of propranolol active pharmaceutical ingredient (API) and related formulations to ensure compliance with ICH guidelines.
• Analytical Method Development: Employed in the development and validation of HPLC, LC-MS, and other chromatographic methods for accurate detection and separation.
• Chemical Synthesis: Acts as a vital synthetic intermediate or starting material for the preparation of other specialized propranolol derivatives and labeled compounds.

Basic Information

Product Name	Rac 7-Hydroxy Propranolol
CAS No.	81907-81-5
Molecular Formula	C₁₆H₂₁NO₃
Molecular Weight	275.35 g/mol
Synonyms	7-Hydroxypropranolol; (±)-7-Hydroxypropranolol; 1-[(1-Methylethyl)amino]-3-(1-naphthalenyloxy)-2-propanol, 7-Hydroxy-; 7-OH-Propranolol; Propranolol, 7-hydroxy-; Propranolol metabolite 7-hydroxy; 2-Propanol, 1-[(1-methylethyl)amino]-3-(1-naphthyloxy)-, 7-hydroxy-
EINECS	Contact for details

Quality Control

Our Rac 7-Hydroxy Propranolol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identification, purity assay, and impurity profiling via advanced techniques like HPLC and LC-MS to ensure it meets high-purity standards suitable for research and development. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Keep the container sealed to protect this light-sensitive material from moisture and atmospheric contaminants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.