Description

α-(Fuoromethyl)-1-Trityl-Dl-Histidine Methyl Ester is a protected, fluorinated derivative of the amino acid histidine, serving as a crucial synthetic intermediate in advanced organic and medicinal chemistry. Its value lies in the strategic incorporation of fluorine and the trityl protecting group, which enables precise chemical modifications for developing novel bioactive compounds. This high-purity building block is essential for researchers and manufacturers in pharmaceutical development, particularly for creating peptide-based therapeutics and targeted molecular probes.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel fluorinated peptide drugs and enzyme inhibitors.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to investigate the impact of fluorination on drug metabolism and binding affinity.
• Peptide Synthesis: Serves as a protected histidine analog for the solid-phase or solution-phase synthesis of complex, modified peptides.
• Proteomics & Biochemical Tool Development: Employed in creating activity-based probes and affinity labels for studying histidine-involved enzymatic processes.
• Radiopharmaceutical Precursor: Potential intermediate for synthesizing fluorine-18 labeled compounds used in Positron Emission Tomography (PET) imaging.
• Agrochemical Research: Intermediate for developing new fluorinated compounds with potential pesticidal or herbicidal activity.

Basic Information

Product Name	α-(Fuoromethyl)-1-Trityl-Dl-Histidine Methyl Ester
CAS No.	81839-25-0
Molecular Formula	C31H29FN3O2
Molecular Weight	494.58 g/mol
Synonyms	1-Trityl-α-(fluoromethyl)histidine methyl ester; DL-1-Trityl-α-(fluoromethyl)histidine methyl ester; Methyl 1-trityl-α-(fluoromethyl)-DL-histidinate; (RS)-1-Trityl-α-(fluoromethyl)histidine methyl ester; α-(Fluoromethyl)-1-trityl-DL-histidine methyl ester; Histidine, α-(fluoromethyl)-1-trityl-, methyl ester, DL-; Fmoc-His(Trt)-α-CH2F-OMe (related protected form); CAS 81839-25-0
EINECS	Contact for details

Quality Control

Our α-(Fuoromethyl)-1-Trityl-Dl-Histidine Methyl Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and specific tests for residual solvents and moisture content. We provide a detailed Certificate of Analysis (COA) with every shipment to ensure traceability and compliance with your research or cGMP starting material requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound is light-sensitive and should be handled under appropriate conditions to maintain stability. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.