Description

m-Peg5-Nitrile is a high-purity, heterobifunctional polyethylene glycol (PEG) derivative featuring a nitrile group at one terminus. This compound is a critical building block in bioconjugation and pharmaceutical development, enabling the precise modification of biomolecules and surfaces. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and advanced materials sectors for creating targeted drug delivery systems, diagnostic agents, and functionalized hydrogels.

Application

• Bioconjugation Linker: Acts as a spacer and functional handle for attaching drugs, dyes, or targeting ligands to antibodies, proteins, and peptides.
• Pharmaceutical Intermediate: Used in the synthesis of prodrugs and antibody-drug conjugates (ADCs) to improve solubility and pharmacokinetic profiles.
• Surface Functionalization: Modifies nanoparticles, quantum dots, and biosensor surfaces to introduce specific reactivity for downstream coupling.
• Polymer Chemistry: Serves as a monomer or cross-linking agent in the synthesis of specialized, biocompatible polymers and hydrogels.
• Click Chemistry Precursor: The nitrile group can be transformed into tetrazoles or other functional groups for bioorthogonal conjugation strategies.
• Diagnostic Reagent Synthesis: Employed in the development of contrast agents and molecular probes for imaging applications.

Basic Information

Product Name	m-Peg5-Nitrile
CAS No.	81836-41-1
Molecular Formula	C15H29NO6
Molecular Weight	319.40 g/mol
Synonyms	m-PEG5-CN; Methoxy-PEG5-nitrile; 2,5,8,11,14-Pentaoxaheptadecan-17-nitrile; 17-Cyano-3,6,9,12,15-pentaoxaheptadec-1-yl methyl ether; 3,6,9,12,15-Pentaoxaheptadecan-1-ol, 17-cyano-, 1-methyl ether; Methyl-PEG5-cyanide; Cyanomethyl-PEG5-methyl ether; α-Methyl-ω-cyanopentaethylene glycol
EINECS	Contact for details

Quality Control

Our m-Peg5-Nitrile is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and pharmaceutical applications. A detailed Certificate of Analysis (COA) is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. The product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.