Description

(-)-(R)-Mexiletine Hydrochloride is the single enantiomer form of the sodium channel blocker mexiletine, offering superior specificity for research and development. This high-purity chiral building block is critical for investigating stereoselective pharmacological effects and developing advanced active pharmaceutical ingredients (APIs). It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and manufacturers focused on enantiomerically pure cardiovascular and neurological therapeutics.

Application

• Pharmaceutical Reference Standard: Used as a certified standard for analytical method development, validation, and quality control of mexiletine-based drug products.
• Enantiopure API Intermediate: Serves as a key chiral synthon in the research-scale synthesis of novel, stereospecific sodium channel blocking agents.
• Mechanistic & Pharmacological Research: Essential for in-vitro and in-vivo studies aimed at understanding the distinct biological activity, metabolism, and toxicity profile of the (R)-enantiomer.
• Analytical Chemistry: Employed in chiral chromatography as a resolution marker and for calibrating analytical instruments like HPLC and LC-MS.
• Preclinical Development: Supports formulation studies and pharmacokinetic/pharmacodynamic (PK/PD) modeling for new drug candidates.

Basic Information

Product Name	(-)-(R)-Mexiletine Hydrochloride
CAS No.	81771-86-0
Molecular Formula	C11H17NO • HCl
Molecular Weight	215.72 g/mol (Free base: 179.26)
Synonyms	(R)-Mexiletine HCl; (R)-1-(2,6-Dimethylphenoxy)-2-propanamine hydrochloride; (R)-Mexitil Hydrochloride; Dexmexiletine Hydrochloride; (R)-(-)-Mexiletine Hydrochloride; (2R)-1-(2,6-Dimethylphenoxy)propan-2-amine hydrochloride; (R)-Kö 1173 Hydrochloride
EINECS	Contact for details

Quality Control

Our (-)-(R)-Mexiletine Hydrochloride is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including chiral purity assay, to ensure identity, potency, and freedom from undesired enantiomers and impurities. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting compliance with stringent in-house specifications. We support development needs with material suitable for use as a pharmaceutical reference standard.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and purity. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0% (on anhydrous basis)
Chiral Purity (Enantiomeric Excess)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Total impurities ≤1.5%; Any single impurity ≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.