Description

(+)-(S)-Mexiletine Hydrochloride CAS NO 81771-85-9 is the single enantiomer form of the sodium channel blocker, mexiletine, offering superior pharmacological specificity. This high-purity chiral intermediate is critical for research and development in precision medicine, particularly for cardiac arrhythmias and neuropathic pain. It is an essential building block for pharmaceutical manufacturers and advanced research institutions focused on enantiomerically pure active pharmaceutical ingredients (APIs).

Application

• Primary raw material for the synthesis of enantiomerically pure Mexiletine API.
• Key chiral intermediate in advanced pharmaceutical research and development (R&D) for cardiac therapeutics.
• Preclinical and clinical study material investigating selective sodium channel blockade.
• Reference standard for analytical method development and quality control (QC) in pharmaceutical laboratories.
• Building block for novel chemical entities targeting voltage-gated sodium channels.
• Used in pharmacological studies to understand stereoselective drug action and metabolism.

Basic Information

Product Name	(+)-(S)-Mexiletine Hydrochloride
CAS No.	81771-85-9
Molecular Formula	C11H17NO • HCl
Molecular Weight	215.72 g/mol (as free base: 179.26)
Synonyms	(S)-Mexiletine HCl; (S)-1-(2,6-Dimethylphenoxy)-2-propanamine hydrochloride; (S)-Mexiletine Hydrochloride; Dexmexiletine Hydrochloride; (S)-Mexitil Hydrochloride; (S)-KOE 1173 Hydrochloride; (2S)-1-(2,6-Dimethylphenoxy)propan-2-amine hydrochloride
EINECS	Contact for details

Quality Control

Our (+)-(S)-Mexiletine Hydrochloride is manufactured under strict quality systems. Each batch is tested to ensure high chemical and enantiomeric purity, meeting the stringent requirements for pharmaceutical intermediates. Comprehensive Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided to support your regulatory and R&D needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under inert conditions or in a desiccator after opening to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.5%
Enantiomeric Purity (Chiral HPLC)	≥99.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Individual impurity ≤0.5%; Total impurities ≤1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.