Description

Bicyclo[2.2.2]Octane-1-Carbonyl Fluoride, 4-Fluoro- (9Ci) is a specialized fluorinated bicyclic building block of significant interest in advanced organic synthesis. This compound matters for its unique, rigid three-dimensional structure and the reactivity of its carbonyl fluoride group, enabling precise molecular construction. It is primarily needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients and complex molecular architectures.

Application

• Pharmaceutical Intermediate: Serves as a key synthon for the development of novel drug candidates, particularly those requiring rigid, three-dimensional scaffolds to enhance binding affinity and metabolic stability.
• Agrochemical Research: Used in the synthesis of advanced pesticide and herbicide molecules, where the fluorinated bicyclic core can impart unique biological activity and environmental persistence profiles.
• Material Science Precursor: Acts as a monomer or cross-linking agent in the development of specialty polymers with tailored thermal and chemical resistance properties.
• Fluorination Reagent: Utilized as a source of the carbonyl fluoride moiety in selective fluorination reactions to introduce fluorine atoms into target molecules.
• Ligand Synthesis: Employed in the creation of sophisticated ligands for catalysis, leveraging its rigid geometry to control metal coordination environments.
• Academic & R&D: A valuable tool in methodological chemistry research for studying reaction mechanisms and developing new synthetic transformations involving strained systems.

Basic Information

Product Name	Bicyclo[2.2.2]Octane-1-Carbonyl Fluoride, 4-Fluoro- (9Ci)
CAS No.	81725-03-3
Molecular Formula	C9H10F2O
Molecular Weight	172.17 g/mol
Synonyms	4-Fluorobicyclo[2.2.2]octane-1-carbonyl fluoride; 1-(Fluoroformyl)-4-fluorobicyclo[2.2.2]octane; 4-Fluoro-bicyclo[2.2.2]octane-1-carboxylic acid fluoride; Bicyclo[2.2.2]octane-1-carbonyl fluoride, 4-fluoro-; 4-Fluoroadamantane-1-carbonyl fluoride (common misnomer based on structure); 4-Fluoro-1-fluorocarbonylbicyclo[2.2.2]octane
EINECS	Contact for details

Quality Control

Our Bicyclo[2.2.2]Octane-1-Carbonyl Fluoride, 4-Fluoro- (9Ci) is produced under stringent quality control protocols to ensure batch-to-batch consistency and high purity for research and development applications. All materials are characterized using advanced analytical techniques including NMR, HPLC, and GC-MS. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from strong acids and incompatible organic solvents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95% (Research Grade)
Purity (GC)	≥ 95%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 1.0%; Total impurities ≤ 5.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.