Description

Pth-4-Hydroxyproline is a protected derivative of the amino acid 4-hydroxyproline, where the amine group is shielded by a phthaloyl (Pth) group. This modification is crucial for its primary role as a key building block and intermediate in the synthesis of complex peptides and peptidomimetics. It is an essential raw material for pharmaceutical research and development, particularly in the production of collagenase inhibitors, novel drug candidates, and advanced biomaterials. The compound is of significant interest to research institutions, fine chemical manufacturers, and pharmaceutical companies engaged in peptide chemistry and medicinal chemistry.

Application

• Intermediate in the solid-phase and solution-phase synthesis of specialized peptides and peptidomimetics.
• Building block for the research and development of collagenase inhibitors and other therapeutic agents targeting connective tissue disorders.
• Key starting material in the preparation of advanced biomaterials and tissue engineering scaffolds.
• Used in the synthesis of labeled compounds for biochemical and pharmacokinetic studies.
• Critical reagent in academic and industrial research exploring proline-rich sequences and their biological functions.
• Precursor for the development of novel drug candidates in oncology, fibrosis, and wound healing applications.

Basic Information

Product Name	Pth-4-Hydroxyproline
CAS No.	81703-65-3
Molecular Formula	C₁₃H₁₁NO₅
Molecular Weight	261.23 g/mol
Synonyms	N-Phthaloyl-4-hydroxy-L-proline; 1-Phthalimido-4-hydroxyproline; 4-Hydroxy-N-phthaloylproline; N-(1,3-Dioxoisoindolin-2-yl)-4-hydroxyproline; PTH-Hyp; N-Phthaloyl-4-hydroxyproline; L-4-Hydroxyproline, N-phthaloyl derivative; 4-Hydroxyproline phthalimide
EINECS	Contact for details

Quality Control

Our Pth-4-Hydroxyproline is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation via IR and NMR spectroscopy, to ensure it meets the high standards required for pharmaceutical research and fine chemical synthesis. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is light-sensitive and should be handled accordingly to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Optical Rotation [α]²⁰D	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.