Description

Acetamide, n-((1S,2R)-2-Hydroxy-1-Methyl-2-Phenylethyl)- is a chiral acetamide derivative of significant interest in advanced organic synthesis. This compound matters as a versatile chiral building block or intermediate, enabling the construction of complex molecules with precise stereochemistry. It is primarily needed by pharmaceutical R&D teams and fine chemical manufacturers developing active pharmaceutical ingredients (APIs), agrochemicals, and specialty materials where stereochemical control is critical.

Application

• Pharmaceutical Intermediate: Key chiral synthon in the synthesis of enantiomerically pure drugs, particularly in central nervous system (CNS) and cardiovascular therapeutic areas.
• Agrochemical Synthesis: Used in the production of chiral pesticides and herbicides, where specific stereoisomers often exhibit enhanced biological activity.
• Catalyst Ligand Precursor: Serves as a starting material for the synthesis of chiral ligands used in asymmetric catalysis (e.g., hydrogenation, cross-coupling).
• Fine Chemical Research: Employed in academic and industrial R&D for exploring new synthetic methodologies and constructing complex natural product analogs.
• Material Science: Potential monomer or modifier in the development of specialty polymers with tailored optical or mechanical properties.

Basic Information

Product Name	Acetamide, n-((1S,2R)-2-Hydroxy-1-Methyl-2-Phenylethyl)-
CAS No.	81703-28-8
Molecular Formula	C12H17NO2
Molecular Weight	207.27 g/mol
Synonyms	(1S,2R)-N-(2-Hydroxy-1-methyl-2-phenylethyl)acetamide; (1S,2R)-2-Acetamido-1-phenylpropan-1-ol; N-[(1S,2R)-2-Hydroxy-1-methyl-2-phenylethyl]acetamide; L-threo-N-Acetyl-1-phenyl-2-aminopropan-1-ol; (1S,2R)-N-Acetyl-1-phenyl-2-aminopropan-1-ol; A Chiral Acetamide Derivative of Phenylpropanolamine
EINECS	Contact for details

Quality Control

Our Acetamide, n-((1S,2R)-2-Hydroxy-1-Methyl-2-Phenylethyl)- is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical and fine chemical applications. Certificates of Analysis (COA) detailing identity, purity, enantiomeric excess, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This compound may be hygroscopic (moisture-sensitive); therefore, the container should be kept tightly sealed to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%, Total impurities ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.