Description

tert-Butyl (2S)-2-(Hydroxymethyl)-5-oxopyrrolidine-1-carboxylate is a high-purity chiral building block and protected amino acid derivative, essential for the synthesis of complex pharmaceutical intermediates. Its value lies in providing a stereochemically defined scaffold that enables the controlled construction of peptidomimetics and other bioactive molecules. This compound is critically needed by research and development chemists in the pharmaceutical and biotechnology industries for the production of active pharmaceutical ingredients (APIs) and novel therapeutic candidates.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of protease inhibitors, neurological agents, and other small-molecule drugs.
• Peptidomimetic Research: Serves as a protected proline or glutamic acid analog for constructing conformationally constrained peptides and macrocycles.
• Asymmetric Synthesis: Utilized as a starting material or auxiliary in catalytic asymmetric reactions to introduce chirality into target molecules.
• API Development: Employed in process chemistry for the scale-up and optimization of new drug candidate production routes.
• Bioconjugation Chemistry: The hydroxymethyl group provides a handle for further functionalization and linker attachment in antibody-drug conjugate (ADC) research.
• Academic & Contract Research: Used in university and CRO laboratories for medicinal chemistry programs and methodology development.

Basic Information

Product Name	tert-Butyl (2S)-2-(Hydroxymethyl)-5-oxopyrrolidine-1-carboxylate
CAS No.	81658-25-5
Molecular Formula	C10H17NO4
Molecular Weight	215.25 g/mol
Synonyms	1-Boc-5-oxo-(S)-prolinol; (S)-1-(tert-Butoxycarbonyl)-5-oxopyrrolidine-2-carboxaldehyde, reduced form; (2S)-2-(Hydroxymethyl)-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidin-5-one; (S)-1-Boc-2-(hydroxymethyl)-5-pyrrolidinone; (S)-2-(Hydroxymethyl)-5-oxo-1-pyrrolidinecarboxylic acid tert-butyl ester; tert-Butyl (S)-2-(hydroxymethyl)-5-oxopyrrolidine-1-carboxylate; Boc-L-5-oxoprolineol
EINECS	Contact for details

Quality Control

Our tert-Butyl (2S)-2-(Hydroxymethyl)-5-oxopyrrolidine-1-carboxylate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including chiral purity verification, to ensure compliance with pharmaceutical-grade standards. Comprehensive Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm
Related Substances (HPLC)	Total impurities ≤1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.