Description

Gastrin Releasing Peptide (14-27) is a defined synthetic peptide fragment corresponding to the C-terminal region of the full-length Gastrin Releasing Peptide (GRP). This high-purity peptide is a critical research tool for investigating the biological functions of GRP, particularly its role as a neurotransmitter and mitogen. It is essential for researchers and developers in the fields of neuroscience, oncology, and gastrointestinal physiology, facilitating studies on receptor binding, signal transduction, and the development of diagnostic or therapeutic agents.

Application

• Biomedical Research: Used as a reference standard and active agent in studies of GRP receptor (GRPR) signaling pathways and function.
• Neuroscience Studies: Investigation of GRP's role in the central nervous system, including its effects on circadian rhythms, anxiety, and satiety.
• Cancer Research: Exploration of GRP's mitogenic effects and its potential role in the proliferation of certain cancer cell lines, such as small cell lung carcinoma.
• Assay Development: Serves as a critical component in the development and validation of immunoassays (ELISA, RIA) and receptor binding assays.
• Pharmaceutical R&D: A key intermediate or reference compound in the discovery and development of GRPR-targeting diagnostics and therapeutics.
• Biochemical Standardization: Used for calibrating analytical instruments and qualifying biological test systems in laboratory settings.

Basic Information

Product Name	Gastrin Releasing Peptide (14-27)
CAS No.	81608-29-9
Molecular Formula	C70H110N24O18S
Molecular Weight	1599.8 g/mol
Synonyms	GRP (14-27); Neuromedin C; Gastrin-Releasing Peptide Fragment 14-27; GRP-14-27; H-His-Trp-Ala-Val-Gly-His-Leu-Met-NH2; L-Histidyl-L-tryptophyl-L-alanyl-L-valylglycyl-L-histidyl-L-leucyl-L-methioninamide; Porcine GRP (14-27)
EINECS	Contact for details

Quality Control

Every batch of Gastrin Releasing Peptide (14-27) is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure identity, purity, and consistency. Our quality assurance protocol includes advanced chromatographic and spectroscopic methods. A comprehensive Certificate of Analysis (COA) detailing purity (by HPLC), amino acid analysis, mass spectrometry (MS) confirmation, and other relevant specifications is provided with each shipment to support your research integrity.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Amino Acid Composition	Conforms to theoretical values
Peptide Content	≥ 80%
Water Content (KF)	≤ 5.0%
Single Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.