Description

Heparin Cofactor Ii CAS NO 81604-65-1 is a serine protease inhibitor (serpin) that plays a critical role in regulating blood coagulation. This protein is essential for researchers and manufacturers developing diagnostic assays and therapeutic agents targeting thrombosis and hemostasis. It is primarily utilized in the life sciences sector for biochemical research, in vitro diagnostic (IVD) reagent production, and as a critical reference material in coagulation studies.

Application

• Biochemical Research: Used as a key reagent in studies of the coagulation cascade, antithrombin-independent heparin mechanisms, and serine protease inhibitor function.
• In Vitro Diagnostic (IVD) Manufacturing: Serves as a critical component in the formulation of diagnostic kits and calibrators for testing blood coagulation disorders.
• Reference Standard: Acts as a purified standard for quality control and assay validation in clinical and research laboratories.
• Therapeutic Development: Investigated in preclinical research for the development of novel antithrombotic and anticoagulant therapies.
• Enzyme Activity Studies: Employed to study the inhibition kinetics of thrombin and other coagulation factors in the presence of glycosaminoglycans like dermatan sulfate.

Basic Information

Product Name	Heparin Cofactor Ii
CAS No.	81604-65-1
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	HCII; Heparin Cofactor II; Dermatan Sulfate Cofactor; SerpinD1; Serpin Family D Member 1; Leupeptin; Antithrombin III-like Protein; Protease Inhibitor HCII
EINECS	Contact for details

Quality Control

Our Heparin Cofactor Ii is produced under stringent quality management systems. Each batch undergoes rigorous analytical testing, including purity assessment by electrophoresis and functional activity assays, to ensure it meets high standards for research and diagnostic use. Certificates of Analysis (COA) detailing purity, activity, and physical characteristics are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. This product is hygroscopic (moisture-sensitive). Avoid repeated freeze-thaw cycles. For laboratory use only.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (SDS-PAGE)	Corresponds to standard
Purity (SDS-PAGE)	> 90%
Biological Activity (Chromogenic Assay)	Contact for details
Protein Content (BCA)	Contact for details
Endotoxin Level (LAL)	< 1.0 EU/µg
Solubility	Soluble in aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.