Description

[6R-(6Alpha,7Beta)]-3-[[(1-Methyl-1H-Tetrazol-5-Yl)Thio]Methyl]-8-Oxo-7-(Phenylacetamido)-5-Thia-1-Azabicyclo[4.2.0]Oct-2-Ene-2-Carboxylic Acid 5-Oxide is a key pharmaceutical intermediate and a derivative of cephalosporin antibiotics. This compound is critical for the synthesis of advanced β-lactam antibiotics, offering a high-purity building block for complex drug manufacturing. It is primarily required by pharmaceutical R&D laboratories, API (Active Pharmaceutical Ingredient) manufacturers, and fine chemical suppliers focused on anti-infective therapies.

Application

• Pharmaceutical Intermediate: Serves as a crucial precursor in the synthesis of third-generation cephalosporin antibiotics.
• Active Pharmaceutical Ingredient (API) Development: Used in research and development for creating new antibacterial agents.
• Reference Standard: Employed as a high-purity analytical standard in quality control laboratories for method development and validation.
• Chemical Synthesis: Acts as a specialized building block for modifying the cephem nucleus to explore new structure-activity relationships.
• Academic & Industrial Research: Utilized in biochemical and pharmacological studies to investigate mechanisms of bacterial resistance and antibiotic efficacy.

Basic Information

Product Name	[6R-(6Alpha,7Beta)]-3-[[(1-Methyl-1H-Tetrazol-5-Yl)Thio]Methyl]-8-Oxo-7-(Phenylacetamido)-5-Thia-1-Azabicyclo[4.2.0]Oct-2-Ene-2-Carboxylic Acid 5-Oxide
CAS No.	81589-25-5
Molecular Formula	C20H20N6O5S2
Molecular Weight	488.54 g/mol
Synonyms	7-Phenylacetamido-3-[(1-methyl-1H-tetrazol-5-yl)thiomethyl]-3-cephem-4-carboxylic acid 1-oxide; Cefazolin Impurity; Cefazolin Related Compound; (6R,7R)-7-(2-Phenylacetamido)-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid 5-oxide; Cefazolin Sulfoxide; Cefazolin EP Impurity; Cefamezin Impurity
EINECS	Contact for details

Quality Control

Our [6R-(6Alpha,7Beta)]-3-[[(1-Methyl-1H-Tetrazol-5-Yl)Thio]Methyl]-8-Oxo-7-(Phenylacetamido)-5-Thia-1-Azabicyclo[4.2.0]Oct-2-Ene-2-Carboxylic Acid 5-Oxide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing including HPLC, NMR, and mass spectrometry to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support compliance with cGMP and ICH Q7 guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed and desiccated to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%, Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.