Description

(S,S)-n-(1-Phenylethyl) Ibuprofen Amide is a high-purity chiral intermediate of significant importance in advanced pharmaceutical synthesis. This compound matters because it serves as a critical building block for the development of enantiomerically pure non-steroidal anti-inflammatory drugs (NSAIDs) and other active pharmaceutical ingredients (APIs). Pharmaceutical R&D laboratories and fine chemical manufacturers need it for process development, analytical method validation, and the production of targeted therapeutics where stereochemical control is paramount.

Application

• Chiral Intermediate in API Synthesis: A key precursor for the production of enantiomerically pure forms of ibuprofen and related 2-arylpropionic acid derivatives.
• Pharmaceutical Research & Development: Used in medicinal chemistry for structure-activity relationship (SAR) studies and the development of novel NSAID candidates.
• Asymmetric Synthesis Aid: Employed as a resolving agent or chiral auxiliary in stereoselective synthetic pathways.
• Reference Standard: Serves as a high-purity analytical standard for quality control and regulatory compliance in pharmaceutical manufacturing.
• Biochemical Research: Used in studies investigating enzyme inhibition, receptor binding, and the metabolic pathways of profen drugs.

Basic Information

Product Name	(S,S)-n-(1-Phenylethyl) Ibuprofen Amide
CAS No.	81576-52-5
Molecular Formula	C21H27NO
Molecular Weight	309.45 g/mol
Synonyms	(S,S)-N-(1-Phenylethyl)-2-(4-isobutylphenyl)propanamide; (S,S)-Ibuprofen (1-Phenylethyl)amide; (S,S)-Ibuprofen α-Methylbenzylamide; (S,S)-N-(α-Methylbenzyl)ibuprofenamide; (2S)-N-[(1S)-1-Phenylethyl]-2-[4-(2-methylpropyl)phenyl]propanamide; (S,S)-IBU-PEA; Ibuprofen (S,S)-PEA amide
EINECS	Contact for details

Quality Control

Our (S,S)-n-(1-Phenylethyl) Ibuprofen Amide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC and NMR, to ensure high enantiomeric excess (ee) and chemical purity meeting the stringent requirements of pharmaceutical applications. Certificates of Analysis (COA) detailing identity, purity, and chiral purity are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment to prevent moisture absorption. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Chiral Purity (Enantiomeric Excess)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.