Description

(S,R)-n-(1-Phenylethyl) Ibuprofen Amide is a chiral amide derivative of ibuprofen, serving as a critical intermediate in advanced pharmaceutical synthesis. This compound is valued for its role in the research and development of enantiomerically pure non-steroidal anti-inflammatory drugs (NSAIDs) and other bioactive molecules. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers focused on chiral resolution and the production of high-value active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key chiral building block in the synthesis of novel ibuprofen derivatives and other NSAID candidates.
• Chiral Resolution Studies: Used as a resolving agent or model compound in developing and optimizing methods for enantiomeric separation.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies to explore new anti-inflammatory and analgesic agents.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method validation in pharmaceutical analysis.
• Asymmetric Synthesis: Utilized in catalytic and stoichiometric asymmetric reactions to introduce chiral complexity.
• Biochemical Research: Investigated for its interaction with enzymes like cyclooxygenase (COX) in biochemical assays.

Basic Information

Product Name	(S,R)-n-(1-Phenylethyl) Ibuprofen Amide
CAS No.	81576-47-8
Molecular Formula	C21H27NO
Molecular Weight	309.45 g/mol
Synonyms	N-[(1S)-1-Phenylethyl]-2-[4-(2-methylpropyl)phenyl]propanamide; N-[(1R)-1-Phenylethyl]-2-[4-(2-methylpropyl)phenyl]propanamide; Ibuprofen (1-phenylethyl)amide; (RS)-N-(1-Phenylethyl)ibuprofenamide; α-Methyl-N-(1-phenylethyl)-[1,1'-biphenyl]-4-acetamide; Ibuprofen Phenethyl Amide; (R,S)-Ibuprofen 1-Phenylethylamide
EINECS	Contact for details

Quality Control

Our (S,R)-n-(1-Phenylethyl) Ibuprofen Amide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric composition, and identity confirmation via spectroscopic methods. We provide a Certificate of Analysis (COA) with each shipment, detailing all critical specifications to ensure compliance with your research and production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment to prevent moisture uptake. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% (S,R mixture as specified)
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.