Description

Isoxepac Glucuronide is a key metabolite of the non-steroidal anti-inflammatory drug (NSAID) Isoxepac. This compound is of significant importance in pharmaceutical research and development, particularly in the fields of drug metabolism and pharmacokinetics (DMPK) studies. It serves as a critical reference standard for analytical method development, bioanalytical testing, and regulatory compliance in the pharmaceutical and biotechnology industries. Researchers and quality control laboratories rely on high-purity Isoxepac Glucuronide for accurate quantification and characterization of drug metabolites in biological matrices.

Application

• Pharmaceutical Reference Standard: Primary use as a certified reference material (CRM) for quantitative analysis in drug development.
• Metabolite Identification & Profiling: Essential for DMPK studies to understand the metabolic pathway and clearance of the parent drug Isoxepac.
• Bioanalytical Method Development & Validation: Used as a calibrant and quality control sample in LC-MS/MS and HPLC assays for preclinical and clinical studies.
• Toxicology & Safety Assessment: Employed in studies to assess the safety profile and potential toxicity of drug metabolites.
• Regulatory Submission Support: Provides essential data for regulatory filings (e.g., with FDA, EMA) requiring characterization of major human metabolites.
• Academic & Contract Research: Serves as a research tool in universities and CROs (Contract Research Organizations) focused on pharmacology and analytical chemistry.

Basic Information

Product Name	Isoxepac Glucuronide
CAS No.	81536-58-5
Molecular Formula	C22H24O10
Molecular Weight	448.42 g/mol
Synonyms	Isoxepac Glucuronide; Isoxepac 1-O-β-Acid Glucuronide; 1-O-(Isoxepac-1-yl)-β-D-Glucopyranuronic Acid; (2S,3S,4S,5R,6S)-6-[(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)oxy]-3,4,5-trihydroxyoxane-2-carboxylic Acid; Glucuronide Metabolite of Isoxepac; Isoxepac β-D-Glucuronide
EINECS	Contact for details

Quality Control

Our Isoxepac Glucuronide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with each shipment, ensuring traceability and compliance with relevant standards for pharmaceutical reference materials. Our commitment is to deliver high-purity, well-characterized metabolites to support critical research and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccant in the container. Allow the vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.