Description

β-Endorphin, Trp(27) is a synthetic peptide analog of the endogenous neuropeptide β-endorphin, specifically modified at the tryptophan-27 position. This compound is of significant interest for its potential role in modulating opioid receptor activity and related physiological pathways. It is primarily utilized by researchers and developers in the fields of neuroscience, pharmacology, and drug discovery for studying pain mechanisms, stress responses, and neuropsychiatric disorders.

Application

• Neuroscience Research: Investigation of endogenous opioid systems, receptor binding studies, and signal transduction pathways.
• Pharmacological Studies: Used as a reference standard or active agent in vitro and in vivo models to study analgesia, addiction, and mood regulation.
• Drug Discovery & Development: Serves as a key intermediate or lead compound for the development of novel analgesics and neurotherapeutics.
• Biochemical Assays: Employed in competitive binding assays (e.g., RIA, ELISA) and functional cellular assays to characterize opioid receptor subtypes.
• Academic & Institutional Research: Fundamental research into the structure-activity relationships (SAR) of endorphin peptides.

Basic Information

Product Name	β-Endorphin, Trp(27)
CAS No.	81514-80-9
Molecular Formula	C158H251N39O46S
Molecular Weight	3466.0 g/mol (approximately)
Synonyms	β-Endorphin (tryptophan-27); [Trp27]-β-Endorphin; β-Endorphin, Tryptophan-27 substituted; Human β-Endorphin (1-31), Trp-27; β-Lipotropin (61-91), Trp-27; Cysteine-free β-Endorphin analog; Opioid peptide analog; END-27Trp
EINECS	Contact for details

Quality Control

Our β-Endorphin, Trp(27) is manufactured under strict quality systems. Each batch undergoes comprehensive analytical testing including HPLC for purity, mass spectrometry (MS) for identity confirmation, and amino acid analysis (AAA). We provide a detailed Certificate of Analysis (COA) with each shipment, ensuring traceability and compliance with research-grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccant and under an inert atmosphere. Allow the vial to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by AAA)
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%
Solubility	Soluble in water, acetic acid, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.