Description

n-[tert-Butyloxycarbonyl]-6-Hydroxy-Dl-Norleucine is a protected amino acid derivative that serves as a critical building block in advanced organic synthesis. Its value lies in the dual functionality provided by the tert-butyloxycarbonyl (Boc) protecting group and the reactive hydroxyl side chain, enabling precise and controlled peptide coupling reactions. This compound is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors, particularly for the development of novel peptide-based therapeutics and complex organic molecules.

Application

• Pharmaceutical Intermediate: A key synthon in the solid-phase and solution-phase synthesis of complex peptides and peptidomimetics for drug discovery.
• Bioconjugation: Used to introduce functionalized amino acid residues into proteins or antibodies for creating antibody-drug conjugates (ADCs) and other bioconjugates.
• Research & Development: Serves as a versatile building block in academic and industrial R&D for exploring new chemical entities and bioactive compounds.
• Custom Peptide Synthesis: Employed by CROs and CDMOs for the custom manufacturing of non-natural amino acid-containing peptides with specific properties.
• Prodrug Development: The Boc-protected hydroxyl group can be utilized in the design of prodrugs to enhance solubility, stability, or targeted delivery.
• Material Science: Potential application in the synthesis of specialized polymers and dendrimers that incorporate amino acid motifs for biomaterials.

Basic Information

Item	Detail
Product Name	n-[tert-Butyloxycarbonyl]-6-Hydroxy-Dl-Norleucine
CAS No.	81505-64-8
Molecular Formula	C11H21NO5
Molecular Weight	247.29 g/mol
Synonyms	Boc-6-Hydroxy-DL-norleucine; (RS)-2-[(tert-Butoxycarbonyl)amino]-6-hydroxyhexanoic acid; 6-Hydroxy-DL-norleucine N-Boc derivative; N-Boc-6-hydroxy-DL-norleucine; DL-6-Hydroxynorleucine, N-Boc-; 2-[(2-Methylpropan-2-yl)oxycarbonylamino]-6-hydroxyhexanoic acid; Boc-Hyl-OH (DL); N-(tert-Butoxycarbonyl)-6-hydroxy-DL-norleucine
EINECS	Contact for details

Quality Control

Our n-[tert-Butyloxycarbonyl]-6-Hydroxy-Dl-Norleucine is produced under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation via IR and NMR spectroscopy, to ensure it meets the high standards required for pharmaceutical R&D. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and purity. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Optical Purity (Chiral HPLC)	DL-mixture
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.