Description

n-Boc-6-Hydroxy-Dl-Norleucine Methyl Ester is a protected amino acid derivative, a crucial building block in organic synthesis. This compound is valued for its role in the preparation of complex peptides and peptidomimetics, where the tert-butoxycarbonyl (Boc) and methyl ester groups provide orthogonal protection strategies. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the development of novel therapeutic agents and bioactive molecules.

Application

• Pharmaceutical Intermediate: A key synthon in the solid-phase and solution-phase synthesis of peptide-based drugs and candidates.
• Protease Inhibitor Research: Used in the design and construction of inhibitors targeting specific enzymatic pathways.
• Bioconjugation Chemistry: Serves as a functionalized linker for attaching peptides to other molecules, surfaces, or carriers.
• Chemical Biology Probes: Employed in the synthesis of labeled or modified peptides for studying protein-protein interactions and cellular processes.
• Academic & Industrial R&D: Fundamental building block for exploring new synthetic methodologies and creating libraries of novel compounds.

Basic Information

Product Name	n-Boc-6-Hydroxy-Dl-Norleucine Methyl Ester
CAS No.	81505-49-9
Molecular Formula	C₁₃H₂₅NO₅
Molecular Weight	275.34 g/mol
Synonyms	6-Hydroxy-DL-norleucine, N-(tert-butoxycarbonyl)-, methyl ester; Methyl N-(tert-butoxycarbonyl)-6-hydroxy-DL-norleucinate; Boc-6-Hydroxy-DL-Nle-OMe; (RS)-Methyl 2-[(tert-butoxycarbonyl)amino]-6-hydroxyhexanoate; DL-2-((tert-Butoxycarbonyl)amino)-6-hydroxyhexanoic acid methyl ester; N-Boc-6-hydroxy-DL-norleucine methyl ester; tert-Butyl (RS)-(6-hydroxy-1-methoxy-1-oxohexan-2-yl)carbamate
EINECS	Contact for details

Quality Control

Our n-Boc-6-Hydroxy-Dl-Norleucine Methyl Ester is produced under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation (IR, NMR) to ensure it meets the high standards required for research and pharmaceutical applications. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. Due to its hygroscopic nature, the container should be kept sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent moisture absorption and decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (DL Ratio)	~50:50 (Racemic)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.