Description

Z-Pyr-Otbu is a specialized tert-butyl ester derivative of a pyrazine carboxylic acid, serving as a crucial protected intermediate in advanced organic synthesis. Its primary value lies in enabling the controlled construction of complex molecules, particularly in the pharmaceutical sector where precise functional group manipulation is essential. This high-purity building block is critically needed by research and development chemists and process scale-up teams in the pharmaceutical, agrochemical, and advanced materials industries for the synthesis of novel active ingredients and functional compounds.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of kinase inhibitors and other targeted therapies.
• Peptide Mimetic Synthesis: Used in the preparation of peptide analogs and mimetics where the tert-butyloxycarbonyl (Boc) or related protecting groups are required.
• Agrochemical Research: Intermediate in the development of new generation herbicides, fungicides, and plant growth regulators.
• Ligand and Catalyst Preparation: Serves as a precursor for creating specialized ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Custom Chemical Synthesis: Employed by contract research and manufacturing organizations (CROs/CMOs) for client-specific custom synthesis projects.
• Academic Research: Used in university and institutional labs for methodological development in heterocyclic and medicinal chemistry.

Basic Information

Product Name	Z-Pyr-Otbu
CAS No.	81470-51-1
Molecular Formula	C16H22N2O4
Molecular Weight	306.36 g/mol
Synonyms	1-[(Benzyloxy)carbonyl]-3-(tert-butoxycarbonyl)pyrazine-2(1H)-one; 1-Cbz-3-Boc-pyrazin-2(1H)-one; Z-3-Boc-2(1H)-pyrazinone; 1-N-Carbobenzoxy-3-N-tert-butoxycarbonyl-2(1H)-pyrazinone; 1-N-Z-3-N-Boc-2-pyrazinone; 1-(Benzyloxycarbonyl)-3-(tert-butoxycarbonyl)-1,2-dihydropyrazin-2-one; Pyrazine-2(1H)-one, 1-[(phenylmethoxy)carbonyl]-3-[(1,1-dimethylethoxy)carbonyl]-
EINECS	Contact for details

Quality Control

Our Z-Pyr-Otbu is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for sensitive synthetic applications. We employ advanced analytical techniques including HPLC, NMR, and mass spectrometry for identity confirmation and impurity profiling. Certificates of Analysis (COA) detailing purity, related substances, and residual solvents are provided with each shipment to support your quality and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound may be hygroscopic; keep the container tightly sealed in a dry environment to prevent moisture uptake which could affect stability and reactivity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Loss on Drying	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.